In recent years there has been a growing recognition of the importance of maternal health and the uterine environment in the later health of children. Many women experience chronic or acute health conditions while pregnant, and a few studies have linked certain conditions with increased pediatric cancer risk. Maternal health care may further involve the use of medications to treat a preexisting condition or a condition that develops during the prenatal period. It is well-established that maternal intake of diethylstilbestrol (DES) causes cancer in offspring, however for most drugs, the evidence on safety in pregnancy is limited.
The aim of this study is to examine common maternal health conditions and prescription drug use in pregnancy in relation to later childhood cancer development.
Specific aims : (1) Create a linked database of all childhood cancers in Denmark (1977-2012) with information on maternal comorbidities and medication use. (2) Examine the relation between maternal comorbid conditions and childhood cancers. (3) Examine the relation between maternal prescription drug use in pregnancy and childhood cancers. Design and methods: A national case-control study using national registries in Denmark, using data from an existing study on childhood cancers in Denmark (n=537,000). Maternal comorbidity information will be available from the Danish National Patient Register (1977-2012), and prescription drug use in pregnancy from the Danish National Prescription Register (1994-2012). Data on demographic, gestational, and other factors will be available from other national registers. Implications: the findings will add evidence on childhood cancer risk among children of mothers with certain health conditions or who took specific medications during pregnancy. The results will indicate if more active monitoring and screening is needed to reduce the potentially increased risk for the unborn child, and can help guide recommendations on medication use in pregnancy.

Public Health Relevance

Cancer is the leading cause of death by disease among children, with 11,210 new cases expected in the US in 2011. Little is known about pediatric cancer etiology. The aim of the proposed study is to examine the risk of childhood cancers with certain maternal comorbid conditions and the intake of prescription drugs in pregnancy.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21CA175959-01A1
Application #
8691193
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Mahabir, Somdat
Project Start
2014-04-14
Project End
2016-03-31
Budget Start
2014-04-14
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Public Health & Prev Medicine
Type
Schools of Public Health
DUNS #
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Dela Cruz, Rica; Grant, Jeanolivia; Heck, Julia E et al. (2018) Disparities in Adverse Perinatal Outcomes Among Pacific Islanders in the Commonwealth of the Northern Mariana Islands. Prev Chronic Dis 15:E29
Hall, Clinton; Ritz, Beate; Cockburn, Myles et al. (2017) Risk of malignant childhood germ cell tumors in relation to demographic, gestational, and perinatal characteristics. Cancer Epidemiol 46:42-49
Contreras, Zuelma A; Hansen, Johnni; Ritz, Beate et al. (2017) Parental age and childhood cancer risk: A Danish population-based registry study. Cancer Epidemiol 49:202-215
Xu, Xiaoqing; Ritz, Beate; Cockburn, Myles et al. (2017) Maternal Preeclampsia and Odds of Childhood Cancers in Offspring: A California Statewide Case-Control Study. Paediatr Perinat Epidemiol 31:157-164
Omidakhsh, Negar; Ganguly, Arupa; Bunin, Greta R et al. (2017) Residential Pesticide Exposures in Pregnancy and the Risk of Sporadic Retinoblastoma: A Report From the Children's Oncology Group. Am J Ophthalmol 176:166-173
Heck, Julia E; Contreras, Zuelma A; Park, Andrew S et al. (2016) Smoking in pregnancy and risk of cancer among young children: A population-based study. Int J Cancer 139:613-6
Vinceti, Marco; Malagoli, Carlotta; Malavolti, Marcella et al. (2016) Does maternal exposure to benzene and PM10 during pregnancy increase the risk of congenital anomalies? A population-based case-control study. Sci Total Environ 541:444-450
Malagoli, Carlotta; Costanzini, Sofia; Heck, Julia E et al. (2016) Passive exposure to agricultural pesticides and risk of childhood leukemia in an Italian community. Int J Hyg Environ Health 219:742-748
Filippini, Tommaso; Heck, Julia E; Malagoli, Carlotta et al. (2015) A review and meta-analysis of outdoor air pollution and risk of childhood leukemia. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 33:36-66
Heck, Julia E; Omidakhsh, Negar; Azary, Saeedeh et al. (2015) A case-control study of sporadic retinoblastoma in relation to maternal health conditions and reproductive factors: a report from the Children's Oncology group. BMC Cancer 15:735