This is a prospective single arm phase II trial of 60 stage IB NSCLC non-diabetic patients who will receive SBRT for definitive management. Subject selection will be limited to cases with available pathology for tumor mutation analysis. Study subjects will receive induction metformin alone (3 weeks) and concurrent metformin with SBRT (1 week). Response to therapy is the primary study outcome and will be assessed after induction and at study completion using [18F]-FDG PET/CT imaging (Fig. 4). The imaging response to induction metformin and combined SBRT plus metformin will be compared using RECIST version 1.1 (Eisenhauer, Therasse et al. 2009) versus PERCIST 1.0 (Wahl, Jacene et al. 2009) response criteria. Multiple expert observers will be utilized to perform repeat measurements for estimation of response variance. Pre-enrollment biopsy specimen tumor mutation analysis will evaluate candidate genes including TP53, Kras, STK11 using semiconductor sequencing (Rothberg, Hinz et al. 2011). Tumor mutation status will be characterized from pre- enrollment biopsy specimens for the candidate genes (TP53, Kras, LKB1) using semiconductor sequencing (Rothberg, Hinz et al. 2011). Statistical models will be developed to predict tumor response (PERCIST v1.0 &RECIST v1.1) to metformin induction and to combined metformin plus SBRT using pre-treatment characteristics - tumor glucose uptake and mutation status. We will estimate the area under the receiver operator characteristic curve (AUROC) for models comprising tumor genotype (tumor mutation) and phenotype (pretreatment SUV) each independently and combined. We will compare models for predictive power and simplicity (Akaike 1974).

Public Health Relevance

Metformin is being used in multiple clinical trials for the treatment of cancer;however it is unclear how metformin affects the most common methods of examining tumor response on trials. It is also unknown how tumor mutations affect the tumor imaging as well as response to metformin. This trial will seek to answer both questions.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21CA182964-01A1
Application #
8768615
Study Section
Special Emphasis Panel (ZRG1-SBIB-W (56))
Program Officer
Vikram, Bhadrasain
Project Start
2014-08-05
Project End
2016-07-31
Budget Start
2014-08-05
Budget End
2015-07-31
Support Year
1
Fiscal Year
2014
Total Cost
$332,000
Indirect Cost
$124,500
Name
University of Texas MD Anderson Cancer Center
Department
Radiation-Diagnostic/Oncology
Type
Other Domestic Higher Education
DUNS #
800772139
City
Houston
State
TX
Country
United States
Zip Code
77030