Recent work in our lab suggests that, during adolescence, asynchronous patterns of development across different brain systems produce a period of increased sensitivity to affective stimuli and diminished capacity for cognitive control. Especially in affectively salient peer contexts, this regulatory imbalance may contribute to adolescents'increased proclivity to engage in risky behaviors (e.g., substance use, unprotected sexual activity, and reckless driving) that significantly threaten their health and well-being. In separate work, we and others have demonstrated the potential to improve adults'cognitive control through targeted working memory (WM) training. In the present proposal, we aim to bridge these two lines of research by using behavioral and neuroimaging methods to test a novel application of WM training to promote adolescents'cognitive control capabilities, and thus reduce risk taking. We hypothesize that adolescents'control over impulsive and automatic behaviors, especially in affectively salient contexts, can be improved through a targeted program of adaptive complex WM training. We further hypothesize that such improved cognitive control will engender trained adolescent participants with enhanced deliberative decision making skills, and hence reduce their proclivity toward risk taking. Using fMRI, we will characterize the mechanisms that underlie these behavioral changes. The PI and co-PI have a recent history of successful collaboration, and combined expertise in the cognitive neuroscience of cognitive control and the psychosocial development of adolescents and young adults. The proposed studies have the potential to greatly inform theoretical models of adolescent behavior, to yield fundamental insights into the processes that affect adolescent decision-making, to determine whether the maturational timetable of cognitive control can be accelerated through training, and to yield a low-cost intervention for reducing adolescent risk behavior.

Public Health Relevance

Excessive risk-taking behavior (substance use, reckless driving, crime, etc.) is the most significant threat to adolescents'health and well-being. Adolescent risk-taking frequently occurs in affectively charged contexts, likely as a result of discordant maturation in the cognitive control and reward processing brain systems that influence decision making. The proposed studies will deploy behavioral and fMRI methodologies to examine the feasibility of using targeted working memory (WM) training to improve brain function in regions associated with cognitive control, and hence increase adolescent'capability to exert self-regulatory control over risky decision making.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DA031436-02
Application #
8467700
Study Section
Cognition and Perception Study Section (CP)
Program Officer
Sirocco, Karen
Project Start
2012-05-15
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
2
Fiscal Year
2013
Total Cost
$183,600
Indirect Cost
$63,600
Name
Temple University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122