The broad, long term goal of this research is to improve the diagnosis and treatment of intracranial atherosclerotic disease (ICAD). The presence of intracranial atherosclerosis results in alterations in cerebral hemodynamics and also puts patients at risk for stroke. The prevalence of ICAD is known to increase with age indicating that is will be an increasing burden on healthcare cost with the aging of the population. Direct evaluation of tissue Oxygen Extraction Fraction (OEF) using positron emission tomography (PET) scans have provided direct insight into the severity, progression and risk of stroke in extra-cranial atherosclerosis (i.e. Carotid artery disease). Intracranial atherosclerosis induces a more focal loss of intracranial perfusion pressure and results in alterations in CBF, CBV, OEF. In this proposed work we will develop a new MRI pulse sequence for the quantification of OEF, verify its accuracy, reliability against PET.

Public Health Relevance

The number of people with atherosclerosis within the brain increases sharply with age and leaves people a high risk for stroke. There is a great to determine whether a person's brain is being adequately fed by oxygen to prevent a stroke. We will develop and validate an imaging method that can identify patients most likely to have a stroke due to poor circulation of blood in their brains.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EB017928-01A1
Application #
8702831
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Pai, Vinay Manjunath
Project Start
2014-03-15
Project End
2016-02-29
Budget Start
2014-03-15
Budget End
2015-02-28
Support Year
1
Fiscal Year
2014
Total Cost
$237,915
Indirect Cost
$73,905
Name
Northwestern University Chicago
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611