This project aims to develop and validate magnetic resonance imaging (MRI) techniques to enable MR-guided focused ultrasound surgery (MRgFUS) treatment of subjects in the presence of implanted metal devices. Relevance: High-intensity focused ultrasound is one of the most promising new non-invasive ablation methods, and was recently clinically approved for the treatment of painful bone metastases. MRI offers excellent tissue contrast for planning treatments and for assessing the results of an ablation as well as for non- invasive real-time monitoring of the ablation using MR thermometry. Unfortunately, some patients with painful bone metastases treatments have previously had metallic implants inserted for stabilization of their bones, or have other devices such as a total hip replacement, which prohibits the use of MRI guidance due to severe image artifacts. Our group, together with others, has made substantial improvements to MRI near orthopedic implants such as spinal fusions and joint replacements. However, these 3D techniques are volumetric, slow, and inappropriate for interactive imaging applications such as MRgFUS. Approach: The proposed research seeks to overcome these limitations by developing a completely new class of rapid, interactive 2D MRI techniques with almost complete image artifact correction near metal. We will apply these specifically to MRgFUS in two specific aims: (1) to develop rapid, interactive T2 and T1 weighted scans that can be used for pre-treatment planning and for post-treatment evaluation using contrast enhancement, and (2) to develop MR thermometry techniques for real-time MRgFUS treatment monitoring in the presence of metal implants. We will validate the metal artifact correction in ex vivo animal and in vivo human studies, and verify appropriate imaging performance (contrast and SNR) in MRgFUS patients without metal who are being treated for periosteal ablations of painful bone cancers. Summary: We will develop rapid MRI approaches to image in the presence of metal with minimal artifacts, and tailor these to the interactive planning, real-time temperature monitoring, and post-treatment evaluation of MRgFUS procedures. Following our initial validation in MRgFUS subjects, this research will enable a larger clinical study to demonstrate efficacy of these methods for routine treatment of patients with metallic implants.

Public Health Relevance

Focused ultrasound surgery (FUS) offers a method to treat tumors and other conditions without conventional surgery, leading to safer, faster, cheaper and more successful procedures. Magnetic resonance imaging (MRI) is often used to plan, monitor and evaluate the treatment procedure, but unfortunately is very challenging in subjects with metallic implants such as hip replacements, or fracture stabilization devices. This research will develop new MRI techniques that work in the presence of metal so that FUS procedures can be used in these subjects.

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21EB019723-01
Application #
8815833
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Liu, Guoying
Project Start
2014-09-26
Project End
2016-06-30
Budget Start
2014-09-26
Budget End
2015-06-30
Support Year
1
Fiscal Year
2014
Total Cost
$200,625
Indirect Cost
$75,625
Name
Stanford University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
009214214
City
Stanford
State
CA
Country
United States
Zip Code
94304