Our algorithm and preliminary data preparation progress was significantly impacted by Superstorm Sandy due to loss of preliminary data and loss of staff time. The goal of this proposed grant is to restore preliminary results and research on causal network biosignature algorithm development to provide the basis for a future R01 application.
We hypothesize that an outcome driven causal network approach will identify biomarkers that are more likely to be causal. We will then combine the identified causal biomarkers weighted by their causal effects into a more stable signature score. The goal of this proposed R21 grant is to restore preliminary results and research on causal network bio signature algorithm development.