The experience of chronic stressors in early childhood, such as family poverty, neighborhood and school chaos, and family conflict have substantial negative consequences for life course physical and mental health, academic achievement, and ultimate social, educational, and economic attainment. With this proposal, we focus on neurobiological mechanisms that link chronic stress associated with family, neighborhood, and school disadvantage to impaired academic achievement. We hypothesize that the association between chronic stress and academic achievement is mediated by the effects of cortisol on executive functions. Executive functions are regulatory processes that support the acquisition of academic skills by allowing the learner to store information temporarily, adapt to task demands, and pay attention to relevant stimuli. Functional magnetic resonance imaging (fMRI) studies indicate that the child brain exhibits characteristic patterns of activation during executive functioning tasks. Many of these same regions have high concentrations of glucocorticoid receptors. Thus, stress-related disruptions in cortisol function are likely to affect the neural bases of executive functions. Cortisol is typically conceptualized s a mediator of the effects of environmental stress; however, genes also influence cortisol function. No previous study has comprehensively tested whether mechanisms underlying cortisol-achievement associations are purely environmental and whether, additionally or alternatively, cortisol is a physiological endophenotype that mediates genetic influences on executive functions and academic achievement. The proposed research will combine cutting-edge methods and technologies from endocrinology and neuroscience with well-developed methods from human ecology and behavioral genetics to explore the associations between chronic stress, cortisol, executive functions, and achievement. We will collect socioecological data, hair cortisol samples, executive function data, and school transcript achievement outcomes from a diverse and population-representative sample of 300 twins (150 pairs, 50% monozygotic) in grade 3, half of whom (N=150 twins from 75 pairs) will participate in fMRI scanning during performance of executive function tasks. This highly innovative and cross-disciplinary approach will allow us to: (1) Test the magnitude and shape of associations between hair cortisol and key study variables - socioecological stress, executive functions, and academic achievement; (2)Test a multivariate model of the mediating roles of cortisol and executive functions on the association between stress and achievement; and (3) Estimate the extent to which key pathways identified in the mediation model occur via genetic and/or environmental mechanisms.

Public Health Relevance

Prolonged exposure to stress during childhood impairs both academic achievement and the executive functions that support learning. Using a population-representative sample of twins in grade 3, this project will investigate interrelations between academic achievement and measures and biomarkers of chronic stress. Results will inform interventions and policies designed to ameliorate inequalities in academic achievement and maximize children's potentials for healthy development and learning.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21HD081437-01A1
Application #
8893694
Study Section
Biobehavioral Mechanisms of Emotion, Stress and Health Study Section (MESH)
Program Officer
Freund, Lisa S
Project Start
2015-04-01
Project End
2017-03-31
Budget Start
2015-04-01
Budget End
2016-03-31
Support Year
1
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
170230239
City
Austin
State
TX
Country
United States
Zip Code
78712
Engelhardt, Laura E; Roe, Mary Abbe; Juranek, Jenifer et al. (2017) Children's head motion during fMRI tasks is heritable and stable over time. Dev Cogn Neurosci 25:58-68
Tucker-Drob, E M; Grotzinger, A D; Briley, D A et al. (2017) Genetic influences on hormonal markers of chronic hypothalamic-pituitary-adrenal function in human hair. Psychol Med :1-13
Tucker-Drob, Elliot M; Briley, Daniel A; Engelhardt, Laura E et al. (2016) Genetically-mediated associations between measures of childhood character and academic achievement. J Pers Soc Psychol 111:790-815
Jelenkovic, Aline; Sund, Reijo; Hur, Yoon-Mi et al. (2016) Genetic and environmental influences on height from infancy to early adulthood: An individual-based pooled analysis of 45 twin cohorts. Sci Rep 6:28496
Engelhardt, Laura E; Mann, Frank D; Briley, Daniel A et al. (2016) Strong genetic overlap between executive functions and intelligence. J Exp Psychol Gen 145:1141-59
Tucker-Drob, Elliot M; Bates, Timothy C (2016) Large Cross-National Differences in Gene × Socioeconomic Status Interaction on Intelligence. Psychol Sci 27:138-149