TB remains one of the leading causes of death from infectious disease worldwide, and treatment adherence a persistent challenge. This is particularly pressing in high-burden, low- resource settings such as Cambodia, where approximately two-thirds of people carry the TB bacterium, one of the highest rates in the world. We propose to develop and pilot a novel smartphone-based intervention to improve TB treatment adherence, integrating video-enabled Directly Observed Therapy (VDOT) with transfers of mobile money and phone ownership to compliant patients. This intervention aims to directly address two of the key barriers to TB treatment adherence in low resource settings where DOT is costly or impractical. First, the video component has the potential to substitute direct in-person observation with time-stamped videos of patients taking their medication. Second, our proposed intervention incorporates incentives to patients for treatment adherence and equipment preservation in the form of mobile money and eventual phone ownership upon treatment completion. In partnership with the National Tuberculosis Program (NTP), we will assess the feasibility of this intervention and of a future randomized study in two districts of Cambodia. First, we will extend and adapt an existing platform for video-enabled medication monitoring (Mobile Interactive Supervised Therapy (MIST)) to incorporate mobile cash payments conditional upon compliance. We then identify and address outstanding technical and usability issues with the platform by conducting an initial 1-month test of the intervention with 10 TB patients. Finally, we conduct a 6-month demonstration study among 50 households in our study locations to assess the acceptability, implementation, and potential for scale up of the intervention. We also aim to assess the practicalities and challenges of a future randomized controlled effectiveness and cost-effectiveness trial. To the best of our knowledge, this study is the first to examine a mHealth intervention for TB that integrates both adherence monitoring and patient incentives into a single platform. The results will be of immediate relevance to the NTP as well as other TB control programs seeking new alternatives to improving adherence, especially where traditional DOT may be infeasible or costly. These results will also be of interest outside the area of TB where adherence to treatment is critical, such as HIV. More generally, the study will provide key insights into mHealth programs in a setting relevant to other developing countries. This project will involve building new capacity in Cambodia for behavioral research, mHealth, and communications through training to the study personnel and general training on conducting TB and/or mHealth research to study partners and other stakeholders in the country.

Public Health Relevance

This project proposes to develop and pilot a novel smartphone-based intervention to improve TB treatment adherence in Cambodia, which integrates video-enabled Directly Observed Treatment (VDOT) with an automated rewards system that transfers mobile money and eventual phone ownership to compliant patients. The results will be of immediate relevance to Cambodia's National TB Control Program (which is partnering with us), our field partner Operation ASHA (a leading TB-focused NGO), as well as other TB control programs seeking new alternatives to improving adherence, especially where traditional DOT may be infeasible or costly, and outside the area of TB where adherence to treatment is critical, such as HIV, and will provide key insights into mHealth programs in a setting relevant to other developing countries. The project will involve building new capacity in Cambodia for behavioral research, mHealth, and communications through hands-on training for study staff in-country, and through general training sessions for internal and external stakeholders.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21TW010592-01
Application #
9342597
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Povlich, Laura
Project Start
2017-12-14
Project End
2019-11-30
Budget Start
2017-12-14
Budget End
2018-11-30
Support Year
1
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Southern California
Department
Social Sciences
Type
Schools of Arts and Sciences
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90033