The goal of this project will be to develop an interdisciplinary network of scientists dedicated to measuring biological risk for late life health outcomes in large representative samples of populations. Biological risk is defined by indictors of physiological state that increase the probability of disease, disability, loss of physical or cognitive functioning, or death. The network will focus on assessing, harmonizing and validating biological risk measurement in populations;expanding measures available for use in populations;and developing methodological approaches for including complex dimensions of health in analytic models. Scientists who will co-direct the network represent the disciplines of epidemiology and demography with named Core network participants in biology, genetics, psychology, economics and medicine. Members of the network will eventually include investigators from most of the major population studies in the U.S. and a number of international studies, researchers in relevant areas, and emerging scholars. Proposed subgroups of the network include measurement and validation, genetics, life-long effects, and innovation. Activities of the network will include designing and carrying out a series of focused meetings, regular conference calls, workshops, and pilot projects to harmonize and develop measurement. The network will develop multiple approaches to the dissemination of modules on collection methods, assay methods, basic training on relevant topics, and analytic methods. Dissemination of harmonizing information will be a major product of the network. The network will promote interdisciplinary, interuniversity, and international research on factors affecting health outcomes common in old age in large community and national population surveys. This is an emerging area of scientific focus in the population sciences which is at an ideal stage of development to benefit from an organized network.

Public Health Relevance

Biological risk represents objective measurement of major dimensions of population health. The level of risk can indicate the health of the population, need for health care treatment in a population, and the effectiveness of that treatment in controlling risk or delaying disease progression, and death. The measurement of biological risk in large populations often requires adoption of methods not used in laboratory settings. This project will improve the methods of measuring health used in populations and improve comparability of results over time and across studies which is important for monitoring population health.

Public Health Relevance

Biological risk represents objective measurement of major dimensions of population health. The level of risk can indicate the health ofthe population, need for health care treatment in a population, and the effectiveness of that treatment in controlling risk or delaying disease progression, and death. The measurement of biological risk in large populations often requires adoption of methods not used in laboratory settings. This project will improve the methods of measuring health used in populations and improve comparability of results over time and across studies which is important for monitoring population health.

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Resource-Related Research Projects (R24)
Project #
5R24AG037898-03
Application #
8310947
Study Section
National Institute on Aging Initial Review Group (NIA)
Program Officer
Nielsen, Lisbeth
Project Start
2010-09-01
Project End
2015-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$200,727
Indirect Cost
$42,210
Name
University of Southern California
Department
None
Type
Other Domestic Higher Education
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Crimmins, Eileen; Kim, Jung Ki; McCreath, Heather et al. (2014) Validation of blood-based assays using dried blood spots for use in large population studies. Biodemography Soc Biol 60:38-48