The theme of the Charles R. Drew University of Medicine and Science (Drew) Minority Drug Abuse Research Program (MIDARP) is """"""""Addiction is a brain disease and it matters."""""""" The molecular, social and environmental mechanisms of all these components of addiction are poorly understood;one of the goals of this MIDARP grant is to further understand some of the important mechanisms of addiction. Recognizing addiction as a chronic, relapsing brain disorder characterized by compulsive drug seeking and use can impact society's overall health and social policy strategies and help diminish the health and social costs associated with drug abuse and addiction. Guided by this theme, the overarching goal of the training and education program is to enhance Drew's capacity to conduct substance abuse research. The three major components of the program are faculty research skill development and education, student recruitment and research training, and university research infrastructure development. The goals of Drew MIDARP are: 1. To provide research development support and experiences to under-represented faculty and staff to facilitate independent substance abuse research careers; 2. To foster interest in substance abuse research among under-represented students and residents by providing educational and research experiences;and 3. To enhance the research infrastructure at Drew to support substance abuse research. The MIDARP program will enhance Drew's substance abuse research capacity by developing faculty research skills to conduct substance abuse research, enhancing student interest in substance abuse research by providing educational and hands-on research opportunities, and by enhancing the research infrastructure. These measures are designed to increase the visibility of substance abuse research and education within the University, and enhance the system for promoting substance abuse research projects. As Drew is in the process of developing a critical mass of investigators, it is necessary that the MIDARP program focus on improving human resources for the conduct of substance abuse research to strengthen the research environment. These improvements include training in biomedical, clinical and behavioral research techniques;intensive education on research development and methodology, research project management techniques, and grantsmanship;and encouraging collaborative efforts with other university faculty and faculty on other research intensive campuses locally and nationally. As junior faculty sharpen their research skills, they will increase their effectiveness in obtaining competitive extramural support for the conduct of substance abuse research and Drew's ability to recruit other research faculty.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Resource-Related Research Projects (R24)
Project #
5R24DA017298-07
Application #
8266449
Study Section
Special Emphasis Panel (ZDA1-MXS-M (05))
Program Officer
Purohit, Vishnudutt
Project Start
2004-09-15
Project End
2014-05-31
Budget Start
2012-06-01
Budget End
2014-05-31
Support Year
7
Fiscal Year
2012
Total Cost
$371,515
Indirect Cost
$108,029
Name
Charles R. Drew University of Medicine & Science
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059
Harris, Kindred K; Zopey, Mohan; Friedman, Theodore C (2016) Metabolic effects of smoking cessation. Nat Rev Endocrinol 12:299-308
Yan, C; Yang, H; Wang, Y et al. (2016) Increased glycogen synthase kinase-3β and hexose-6-phosphate dehydrogenase expression in adipose tissue may contribute to glucocorticoid-induced mouse visceral adiposity. Int J Obes (Lond) 40:1233-41
Lutfy, K; Parikh, D; Lee, D L et al. (2016) Prohormone convertase 2 (PC2) null mice have increased mu opioid receptor levels accompanied by altered morphine-induced antinociception, tolerance and dependence. Neuroscience 329:318-25
Wang, Ying; Yan, Chaoying; Liu, Limei et al. (2015) 11β-Hydroxysteroid dehydrogenase type 1 shRNA ameliorates glucocorticoid-induced insulin resistance and lipolysis in mouse abdominal adipose tissue. Am J Physiol Endocrinol Metab 308:E84-95
Mojtahedzadeh, Mona; Lee, Martin L; Friedman, Theodore C (2015) Continuation or discontinuation of pioglitazone when starting bedtime insulin in patients with poorly controlled type 2 diabetes in an inner-city population. J Diabetes Complications 29:1248-52
Sinha-Hikim, I; Duran, P; Shen, R et al. (2015) Effect of long term vitamin D supplementation on biomarkers of inflammation in Latino and African-American subjects with pre-diabetes and hypovitaminosis D. Horm Metab Res 47:280-3
Ivey, R; Desai, M; Green, K et al. (2014) Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res 46:568-73
Wang, Ying; Liu, Limei; Du, Hanze et al. (2014) Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab 306:E543-51
Sinha-Hikim, Indrani; Friedman, Theodore C; Shin, Chang-Sung et al. (2014) Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology 155:865-72
O'Dell, Laura E; Natividad, Luis A; Pipkin, Joseph A et al. (2014) Enhanced nicotine self-administration and suppressed dopaminergic systems in a rat model of diabetes. Addict Biol 19:1006-19

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