The theme of the Charles R. Drew University of Medicine and Science (Drew) Minority Drug Abuse Research Program (MIDARP) is "Addiction is a brain disease and it matters." The molecular, social and environmental mechanisms of all these components of addiction are poorly understood;one of the goals of this MIDARP grant is to further understand some of the important mechanisms of addiction. Recognizing addiction as a chronic, relapsing brain disorder characterized by compulsive drug seeking and use can impact society's overall health and social policy strategies and help diminish the health and social costs associated with drug abuse and addiction. Guided by this theme, the overarching goal of the training and education program is to enhance Drew's capacity to conduct substance abuse research. The three major components of the program are faculty research skill development and education, student recruitment and research training, and university research infrastructure development. The goals of Drew MIDARP are: 1. To provide research development support and experiences to under-represented faculty and staff to facilitate independent substance abuse research careers; 2. To foster interest in substance abuse research among under-represented students and residents by providing educational and research experiences;and 3. To enhance the research infrastructure at Drew to support substance abuse research. The MIDARP program will enhance Drew's substance abuse research capacity by developing faculty research skills to conduct substance abuse research, enhancing student interest in substance abuse research by providing educational and hands-on research opportunities, and by enhancing the research infrastructure. These measures are designed to increase the visibility of substance abuse research and education within the University, and enhance the system for promoting substance abuse research projects. As Drew is in the process of developing a critical mass of investigators, it is necessary that the MIDARP program focus on improving human resources for the conduct of substance abuse research to strengthen the research environment. These improvements include training in biomedical, clinical and behavioral research techniques;intensive education on research development and methodology, research project management techniques, and grantsmanship;and encouraging collaborative efforts with other university faculty and faculty on other research intensive campuses locally and nationally. As junior faculty sharpen their research skills, they will increase their effectiveness in obtaining competitive extramural support for the conduct of substance abuse research and Drew's ability to recruit other research faculty.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Resource-Related Research Projects (R24)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-MXS-M (05))
Program Officer
Purohit, Vishnudutt
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Charles R. Drew University of Medicine & Science
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
Zip Code
Wang, Ying; Liu, Limei; Du, Hanze et al. (2014) Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab 306:E543-51
Ivey, R; Desai, M; Green, K et al. (2014) Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res 46:568-73
Sinha-Hikim, Indrani; Friedman, Theodore C; Shin, Chang-Sung et al. (2014) Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology 155:865-72
Marquez, Paul; Hamid, Abdul; Lutfy, Kabirullah (2013) The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice. Eur J Pharmacol 707:41-5
Davidson, Mayer B; Duran, Petra; Lee, Martin L et al. (2013) High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care 36:260-6
Ren, Xiuhai; Lutfy, Kabirullah; Mangubat, Michael et al. (2013) Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes 2013:764742
Du, Hanze; Liu, Limei; Wang, Ying et al. (2013) Specific reduction of G6PT may contribute to downregulation of hepatic 11ýý-HSD1 in diabetic mice. J Mol Endocrinol 50:167-78
Nie, Ying; Ferrini, Monica G; Liu, Yanjun et al. (2013) Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides 47:99-109
Tseng, Andy; Nguyen, Khanh; Hamid, Abdul et al. (2013) The role of endogenous beta-endorphin and enkephalins in ethanol reward. Neuropharmacology 73:290-300
Natividad, Luis A; Torres, Oscar V; Friedman, Theodore C et al. (2013) Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behav Brain Res 257:275-85

Showing the most recent 10 out of 31 publications