Although smoking cessation efforts by NIDA and others have been successful, millions of Americans continue to smoke. Additionally, our laboratories have found important results on the metabolic effects of nicotine, including findings that nicotine plus a high fat diet (HFD) leads to hepatic and muscle steatosis. We have also used a large database to show that secondhand smoke is associated with both diabetes and obesity. This has led us to develop the theme of the Charles R. Drew University of Medicine and Science (CDU) Diversity-Promoting Institution Drug Abuse Research Program (DIDARP) to be "Metabolic Effects of Nicotine: it Matters." Our training theme will continue to be "Research Teams of the Future" that is based on the NIH roadmap. Our training program will focus on minority trainees at all levels and make a difference in the long run by tackling the problem of substance abuse. The overarching goal of the research, training and education programs of this DIDARP are to enhance CDU's capacity to conduct substance abuse research with a primary focus on the metabolic effects of nicotine. The specific goals of CDU DIDARP are: 1. To increase the number of high quality drug addiction research projects related to the metabolic effects of nicotine to allow CDU to develop expertise and acquire preliminary data to be able to compete for NIDA P01, P50 or ROI grants; 2. To continue to foster interest in substance abuse research among under-represented students and other trainees by providing meaningful educational and research experiences;and 3. To continue to enhance the research infrastructure at CDU to support substance abuse research. To achieve these goals, we will have 3 related, cross-disciplinary projects: Project 1: Nicotine exacerbates high fat diet-induced hepatic steatosis and skeletal muscle abnormalities in obese mice. Pilot Project A: Understanding the role of dopamine in binge-eating, nicotine and alcohol use: a translational PET study. Pilot Project B: The association between secondhand smoking and diabetes, obesity and other chronic diseases. Achieving these goals will eventually help reduce the health disparities as related to substance abuse.

Public Health Relevance

Much remains unknown about the devastating consequences of cigarettes and the mechanisms of how nicotine, the main active compound in cigarettes, leads to these effects. The theme of the CDU DIDARP is the Metabolic Effects of Nicotine: It Matters and in one primary project and two pilot projects, we will study the deleterious metabolic effects of nicotine in a multidisciplinary, highly translational manner. Our training program will focus on minority trainees at all levels and we will develop faculty at CDU. The CDU DIDARP, by tackling the problem of cigarette smoking, will have important public health implications.

National Institute of Health (NIH)
Resource-Related Research Projects (R24)
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Special Emphasis Panel (ZDA1)
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Purohit, Vishnudutt
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Charles R. Drew University of Med & Sci
Internal Medicine/Medicine
Schools of Medicine
Los Angeles
United States
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Wang, Ying; Liu, Limei; Du, Hanze et al. (2014) Transgenic overexpression of hexose-6-phosphate dehydrogenase in adipose tissue causes local glucocorticoid amplification and lipolysis in male mice. Am J Physiol Endocrinol Metab 306:E543-51
Ivey, R; Desai, M; Green, K et al. (2014) Additive effects of nicotine and high-fat diet on hepatocellular apoptosis in mice: involvement of caspase 2 and inducible nitric oxide synthase-mediated intrinsic pathway signaling. Horm Metab Res 46:568-73
Sinha-Hikim, Indrani; Friedman, Theodore C; Shin, Chang-Sung et al. (2014) Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice. Endocrinology 155:865-72
Marquez, Paul; Hamid, Abdul; Lutfy, Kabirullah (2013) The role of NOP receptors in psychomotor stimulation and locomotor sensitization induced by cocaine and amphetamine in mice. Eur J Pharmacol 707:41-5
Davidson, Mayer B; Duran, Petra; Lee, Martin L et al. (2013) High-dose vitamin D supplementation in people with prediabetes and hypovitaminosis D. Diabetes Care 36:260-6
Ren, Xiuhai; Lutfy, Kabirullah; Mangubat, Michael et al. (2013) Alterations in phosphorylated CREB expression in different brain regions following short- and long-term morphine exposure: relationship to food intake. J Obes 2013:764742
Du, Hanze; Liu, Limei; Wang, Ying et al. (2013) Specific reduction of G6PT may contribute to downregulation of hepatic 11ýý-HSD1 in diabetic mice. J Mol Endocrinol 50:167-78
Nie, Ying; Ferrini, Monica G; Liu, Yanjun et al. (2013) Morphine treatment selectively regulates expression of rat pituitary POMC and the prohormone convertases PC1/3 and PC2. Peptides 47:99-109
Tseng, Andy; Nguyen, Khanh; Hamid, Abdul et al. (2013) The role of endogenous beta-endorphin and enkephalins in ethanol reward. Neuropharmacology 73:290-300
Natividad, Luis A; Torres, Oscar V; Friedman, Theodore C et al. (2013) Adolescence is a period of development characterized by short- and long-term vulnerability to the rewarding effects of nicotine and reduced sensitivity to the anorectic effects of this drug. Behav Brain Res 257:275-85

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