The long-range goal of the proposed MIDARP program described in this application is to increase the capacity of Meharry Medical College to conduct rigorous research in drug abuse and addiction with an emphasis on health disparities and clinically underserved populations. The research program will seek to understand the molecular and behavioral basis for the in-vivo responses to acute and chronic methamphetamine (METH) exposures. We also plan to strengthen our intellectual environment and enhance the interest levels of trainees and faculty in drug abuse research.
The Specific Aims of the Meharry Medical College MIDARP Program during the next five years are: 1. To publish at least 10 or more peer-reviewed publications in high-impact journals in drug abuse research;2. To submit 4 or more applications for grants in drug abuse research by year-03 of the proposed award period;3. To acquire 3 or more investigator-initiated awards by the end of year-05;and 4. To stimulate additional faculty and trainee interest in drug abuse research by curricula enhancement, seminars and symposia. One primary and one pilot research projects are proposed, all from junior investigators. In the primary project, Dr. H. Khoshbouei will characterize the biophysical properties of the dopamine transporter in response to METH versus amphetamine in an effort to understand the greater addictive potential of METH. Dr. Chirwa will characterize the impact of prenatal METH exposure on cellular (electrophysiological and molecular) correlates of adult memory and learning. This program will, thus, seek to understand the effect of Methamphetamine on the brain while stimulating the interests of other faculty members and trainees in drug abuse research.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Resource-Related Research Projects (R24)
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Special Emphasis Panel (ZDA1-MXS-M (05))
Program Officer
Purohit, Vishnudutt
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Meharry Medical College
Schools of Medicine
United States
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Swepson, Chelsie; Ranjan, Alok; Balasubramaniam, Muthukumar et al. (2016) Cocaine Enhances HIV-1 Transcription in Macrophages by Inducing p38 MAPK Phosphorylation. Front Microbiol 7:823
Kaneshiro, Bliss; Edelman, Alison; Dash, Chandravanu et al. (2016) Effect of oral contraceptives and doxycycline on endometrial MMP-2 and MMP-9 activity. Contraception 93:65-9
Addai, Amma B; Pandhare, Jui; Paromov, Victor et al. (2015) Cocaine modulates HIV-1 integration in primary CD4+ T cells: implications in HIV-1 pathogenesis in drug-abusing patients. J Leukoc Biol 97:779-90
Lee, Kiera-Nicole; Chirwa, Sanika (2015) Blocking Dopaminergic Signaling Soon after Learning Impairs Memory Consolidation in Guinea Pigs. PLoS One 10:e0135578
Pandhare, Jui; Dash, Sabyasachi; Jones, Bobby et al. (2015) A Novel Role of Proline Oxidase in HIV-1 Envelope Glycoprotein-induced Neuronal Autophagy. J Biol Chem 290:25439-51
Morris, Matthew C; Walker, Lynn; Bruehl, Stephen et al. (2015) Race Effects on Conditioned Pain Modulation in Youth. J Pain 16:873-80
Yang, Hongyu; Spence, Jeffrey S; Briggs, Richard W et al. (2015) Interaction between early life stress and alcohol dependence on neural stress reactivity. Addict Biol 20:523-33
Morris, Matthew C; Walker, Lynn; Bruehl, Stephen et al. (2015) Race effects on temporal summation to heat pain in youth. Pain 156:917-22
Passaro, Ryan Colby; Pandhare, Jui; Qian, Han-Zhu et al. (2015) The Complex Interaction Between Methamphetamine Abuse and HIV-1 Pathogenesis. J Neuroimmune Pharmacol 10:477-86
Pandhare, Jui; Addai, Amma B; Mantri, Chinmay K et al. (2014) Cocaine enhances HIV-1-induced CD4(+) T-cell apoptosis: implications in disease progression in cocaine-abusing HIV-1 patients. Am J Pathol 184:927-36

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