This application is for the establishment of a University of Alabama at Birmingham (UAB) Digestive Diseases Research Development Center (DDRDC), focusing on the interaction between microbes and the host in mucosal tissues. Principal among the microbes to be studied will be HIV-1, which enters the host through the gastrointestinal and genital tract mucosae; Helicobacter pylori, the most common cause of gastric inflammatory disease; and the commensal bacterial flora, which plays a critical role in the pathogenesis of inflammatory bowel disease. UAB's mucosal immunologists, recognized for their leadership in the study of mucosal pathogens and mucosal ceil immunobiology, have heretofore collaborated individually in an informal, project-oriented manner. We believe that a DDRDC will synergize the research efforts of these investigators into a world-class, program-oriented, mucosal immunology research group more capable of accomplishing breakthroughs in digestive diseases research. Accordingly, the goals for a DDRDC at UAB are the following: (1) Provide an efficient and effective mechanism for expediting, expanding and fostering research in the interaction between microbes, especially HIV-t, H. pylori and the commensal flora, mucoal [sic] epithelium and mucosal innate and adaptive immune cells. (2) Coordinate and pool University-wide resources otherwise not available to individual UAB mucosal immunoogists [sic] in a cost-effective, user-friendly Center. (3) Provide a resource-, expertise- and intellectual-rich environment to generate new concepts in mucosal HIV-1, H. pylori and commensal microbe immunobiology, resulting in new initiatives inte [sic] and investigators in digestive diseases research. These goals will be accomplished through three Cores, including a (1) Genetically-Defined [sic] Microbe and Expression Core, (2) Cell and Molecular Pathology Core, and (3) Gnotobiotic and Genetically-Engineered [sic] Mouse Core. These Cores will promote digestive disease research at UAB and enhance the goals of the DDRDC program. Since the space and equipment for each Core are largely in place, this application seeks funding to staff, supply and run the Cores. In summary, the goals and components described above define the proposed UAB DDRDC.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects (R24)
Project #
5R24DK064400-05
Application #
7242641
Study Section
Special Emphasis Panel (ZDK1-GRB-6 (J1))
Program Officer
Podskalny, Judith M,
Project Start
2003-06-01
Project End
2008-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
5
Fiscal Year
2007
Total Cost
$468,964
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Ruby, John; Martin, Michael; Passineau, Michael J et al. (2018) Activation of the Innate Immune System by Treponema denticola Periplasmic Flagella through Toll-Like Receptor 2. Infect Immun 86:
Li, Mao; Boddeda, Srinivasa Rao; Chen, Bo et al. (2018) NK cell and Th17 responses are differentially induced in murine cytomegalovirus infected renal allografts and vary according to recipient virus dose and strain. Am J Transplant 18:2647-2662
Tanner, Scott M; Daft, Joseph G; Hill, Stephanie A et al. (2016) Altered T-Cell Balance in Lymphoid Organs of a Mouse Model of Colorectal Cancer. J Histochem Cytochem 64:753-767
Mrug, Michal; Zhou, Juling; Yang, Chaozhe et al. (2015) Genetic and Informatic Analyses Implicate Kif12 as a Candidate Gene within the Mpkd2 Locus That Modulates Renal Cystic Disease Severity in the Cys1cpk Mouse. PLoS One 10:e0135678
Bimczok, D; Kao, J Y; Zhang, M et al. (2015) Human gastric epithelial cells contribute to gastric immune regulation by providing retinoic acid to dendritic cells. Mucosal Immunol 8:533-44
Shen, Ruizhong; Achenbach, Jenna; Shen, Yue et al. (2015) Mother-to-Child HIV-1 Transmission Events Are Differentially Impacted by Breast Milk and Its Components from HIV-1-Infected Women. PLoS One 10:e0145150
Tanner, Scott M; Berryhill, Taylor F; Ellenburg, James L et al. (2015) Pathogenesis of necrotizing enterocolitis: modeling the innate immune response. Am J Pathol 185:4-16
Daft, Joseph G; Lorenz, Robin G (2015) Role of the gastrointestinal ecosystem in the development of type 1 diabetes. Pediatr Diabetes 16:407-18
Wolf, Kyle J; Daft, Joseph G; Tanner, Scott M et al. (2014) Consumption of acidic water alters the gut microbiome and decreases the risk of diabetes in NOD mice. J Histochem Cytochem 62:237-50
Brawner, Kyle M; Morrow, Casey D; Smith, Phillip D (2014) Gastric microbiome and gastric cancer. Cancer J 20:211-6

Showing the most recent 10 out of 164 publications