Worldwide, mucosal infections are a major source of morbidity and mortality. The development of innovative therapies and vaccines for such infections will require new insights into the interaction between the causative microorganism and mucosal cells. To this end, University of Alabama at Birmingham (UAB) investigators have focused on HIV-1 pathogenesis and vaccine development, Helicobacter pylori pathogenesis, and immune regulation of inflammatory responses to commensal bacteria. Investigators study the interaction between the microbes and mucosal cells, including epithelial cells and lamina propria lymphocytes, macrophages and dendritic cells. To synergize these UAB investigators into a cohesive research force more capable of conducting pioneering research into the interaction between microbes and host mucosal cells, the Mucosal HIV and Immunobiology Center was established June 1, 2003.
The Specific Aims of the Center are to: (1) Provide an efficient and effective mechanism to expedite, expand and foster research in the interaction between microbes (HIV-1, H. pylori and commensal bacteria) and mucosal cells (epithelial cells and innate and adaptive immune cells); (2) Coordinate and pool University-wide resources otherwise not available to individual UAB mucosal immunologists in a cost-effective, user-friendly Center; (3) Provide a resource-, expertise- and intellectual-rich environment to generate new concepts in mucosal HIV-1, H. pylori and commensal microbe immunobiology, resulting in new initiatives and the recruitment of new investigators to digestive diseases research. To accomplish these aims, the Center established three state-of-the-art Cores: (1) The Genetically- Defined Microbe Core, (2) The Molecular Pathology and Human Cell/Tissue Core and (3) The Gnotobiotic and Genetically-Engineered Mouse Core. By providing the technical infrastructure, intellectual environment and collegial setting for the exchange of ideas and research expertise, services and tools, Center investigators have been integrated into a highly interactive group with far more research strength, opportunity and potential than the sum of the individual investigators and their programs. As a result of this synergy, in only 3 1/2 years the Center has doubled its membership and NIDDK Base Grant support for digestive disease research on the UAB campus.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects (R24)
Project #
5R24DK064400-10
Application #
8281679
Study Section
Special Emphasis Panel (ZDK1-GRB-G (O1))
Program Officer
Podskalny, Judith M,
Project Start
2003-06-01
Project End
2013-05-31
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
10
Fiscal Year
2012
Total Cost
$471,250
Indirect Cost
$146,250
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Brosius, Stephanie N; Turk, Amy N; Byer, Stephanie J et al. (2014) Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades. J Neuropathol Exp Neurol 73:1078-90
Wolf, Kyle J; Daft, Joseph G; Tanner, Scott M et al. (2014) Consumption of acidic water alters the gut microbiome and decreases the risk of diabetes in NOD mice. J Histochem Cytochem 62:237-50
Shen, Ruizhong; Kappes, John C; Smythies, Lesley E et al. (2014) Vaginal myeloid dendritic cells transmit founder HIV-1. J Virol 88:7683-8
Das, Soumita; Sarkar, Arup; Ryan, Kieran A et al. (2014) Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J 28:2214-24
Shen, Ruizhong; Smith, Phillip D (2014) Mucosal correlates of protection in HIV-1-exposed sero-negative persons. Am J Reprod Immunol 72:219-27
Brawner, Kyle M; Morrow, Casey D; Smith, Phillip D (2014) Gastric microbiome and gastric cancer. Cancer J 20:211-6
Shen, Ruizhong; Richter, Holly E; Smith, Phillip D (2014) Interactions between HIV-1 and mucosal cells in the female reproductive tract. Am J Reprod Immunol 71:608-17
Smith, Phillip D; Shimamura, Masako; Musgrove, Lois C et al. (2014) Cytomegalovirus enhances macrophage TLR expression and MyD88-mediated signal transduction to potentiate inducible inflammatory responses. J Immunol 193:5604-12
Basu, Rajatava; Hatton, Robin D; Weaver, Casey T (2013) The Th17 family: flexibility follows function. Immunol Rev 252:89-103
Bimczok, Diane; Smythies, Lesley E; Waites, Ken B et al. (2013) Helicobacter pylori infection inhibits phagocyte clearance of apoptotic gastric epithelial cells. J Immunol 190:6626-34

Showing the most recent 10 out of 134 publications