""""""""Inflammation and the Host Response to Injury"""""""" is one of the Large-Scale Collaborative Project Awards of the National Institute of General Medical Sciences (NIGMS). Commonly known as the Glue Grants program, the stated purpose of these awards was """"""""to enable the solution of major problems in biomedical research and to facilitate the next evolutionary stage of integrative biomedical science"""""""". Our Glue Grant investigators agreed that the most important biological problem to tackle in the area of injury research centered on the innate inflammatory response, and specifically, to improve our systems level understanding of the key regulatory elements, and their relative roles and importance that drive the host's response to serious injury and its accompanying severe systemic inflammation. The problem could only be addressed by first acquiring large amounts of new data in a discovery-driven approach. The start-up costs associated with our introduction of high throughput genomics in clinical medicine in terms of time, effort, and money have been substantial. An important strategy for our investigators is to sustain the infrastructure, resources, tools, and methodologies developed in this Glue Grant through funding collaborations with other federal funding agencies, industry, and/or other nonprofit organizations. Funding opportunity PAR-10-261 allows us to seek financial support to preserve the availability of our unique datasets as resources """"""""not yet self-sustaining"""""""" and to improve the usability of the visualization tools we have created to store, organize, archive, analyze, and visualize the data generated by our program. There are three specific aims that define the activities for maintaining and enhancing our existing bioinformatics databases and tools. (1) Optimize the TRDB information system deployed and in production during the Glue Grant program. (2) Enhance the user-friendly web interface environment by improving the linkage between databases, models, algorithms, and visualization tools. (3) Optimize the display of the heterogeneous datasets, to allow the first-of-its-kind comparative analyses between differing injury types, cell/tissue types, time point sampling, and time course.
This grant allows us to create a legacy resource management system to preserve the data for the scientific community to pursue hypotheses, correlations, or interventions of trauma and burn patient outcomes and recovery from injury.
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|Sweeney, Timothy E; Khatri, Purvesh (2017) Benchmarking Sepsis Gene Expression Diagnostics Using Public Data. Crit Care Med 45:1-10|
|Sood, Ravi F; Gibran, Nicole S; Arnoldo, Brett D et al. (2016) Early leukocyte gene expression associated with age, burn size, and inhalation injury in severely burned adults. J Trauma Acute Care Surg 80:250-7|
|Mathias, Brittany; Lipori, Gigi; Moldawer, Lyle L et al. (2016) Integrating ""big data"" into surgical practice. Surgery 159:371-4|
|Jeschke, Marc G; Pinto, Ruxandra; Kraft, Robert et al. (2015) Morbidity and survival probability in burn patients in modern burn care. Crit Care Med 43:808-15|
|Sweeney, Timothy E; Khatri, Purvesh (2015) Comprehensive Validation of the FAIM3:PLAC8 Ratio in Time-matched Public Gene Expression Data. Am J Respir Crit Care Med 192:1260-1|
|Warren, H Shaw; Tompkins, Ronald G; Moldawer, Lyle L et al. (2015) Mice are not men. Proc Natl Acad Sci U S A 112:E345|
|Nacionales, Dina C; Szpila, Benjamin; Ungaro, Ricardo et al. (2015) A Detailed Characterization of the Dysfunctional Immunity and Abnormal Myelopoiesis Induced by Severe Shock and Trauma in the Aged. J Immunol 195:2396-407|
|Vanzant, Erin L; Ozrazgat-Baslanti, Tezcan; Liu, Huazhi et al. (2015) Clostridium difficile Infections after Blunt Trauma: A Different Patient Population? Surg Infect (Larchmt) 16:421-7|
|Vanzant, Erin L; Hilton, Rachael E; Lopez, Cecilia M et al. (2015) Advanced age is associated with worsened outcomes and a unique genomic response in severely injured patients with hemorrhagic shock. Crit Care 19:77|
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