Computer simulation has revolutionized science and engineering. The PIs propose to establish a National Center for Simulation in Rehabilitation Research to bring the power of simulation to medical rehabilitation. The Center will provide robust tools for simulating human motion, enabling investigators to answer clinical questions that cannot be solved with experimental studies alone. Hundreds of scientists affiliated with the Center will focus on critical areas of rehabilitation, including stroke, spinal cord injury, cerebral palsy, osteoarthritis, prosthetics, orthotics, and sports medicine. The PIs will pursue the following specific aims. 1. Develop and disseminate advanced technology for the simulation of musculoskeletal dynamics and accelerate its appropriate use in rehabilitation research. 2. Award seed grants to innovative and meritorious pilot projects that employ simulation tools to identify the mechanisms underlying movement disorders and improve the efficacy of rehabilitation. 3. Attract and train 20 talented scholars from computer science, biomechanics, physical therapy and other fields to become experts in simulation and the needs of individuals with disabilities. 4. Teach over 300 rehabilitation scientists to create and test biomechanical simulations and correctly interpret their results during intensive multi-day workshops. 5. Introduce over 1000 rehabilitation specialists to the value and limitations of musculoskeletal simulation through hands-on training at national and international conferences. 6. Create web-based tutorials, lectures, and a formal textbook to promote the appropriate use of simulation in rehabilitation research. The development and dissemination of open source software for the rehabilitation community addresses a critical barrier to progress in the field. The software will be designed in close partnership with rehabilitation scientists and physicians to address critical, clinically motivated questions across the spectrum of medical rehabilitation. There is a rapidly growing community of rehabilitation scientists eager to engage in this project;thus, the timing for establishing this core resource is excellent.

Public Health Relevance

This project will develop state-of-the-art simulation software and train rehabilitation researchers to create highly accurate simulations of human movement that can be used to improve treatment for individuals with physical disabilities. Hundreds of researchers will contribute their specialized expertise in muscle biology, neuroscience, bioengineering, computer science, and rehabilitation to identify the mechanisms by which physical impairments limit participation and provide a scientific basis for improving function.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Resource-Related Research Projects (R24)
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Study Section
Special Emphasis Panel (ZHD1-RRG-K (13))
Program Officer
Nitkin, Ralph M
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Stanford University
Biomedical Engineering
Schools of Medicine
United States
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Demers, Matthew S; Pal, Saikat; Delp, Scott L (2014) Changes in tibiofemoral forces due to variations in muscle activity during walking. J Orthop Res 32:769-76
Webb, Joshua D; Blemker, Silvia S; Delp, Scott L (2014) 3D finite element models of shoulder muscles for computing lines of actions and moment arms. Comput Methods Biomech Biomed Engin 17:829-37
Yong, Jennifer R; Silder, Amy; Delp, Scott L (2014) Differences in muscle activity between natural forefoot and rearfoot strikers during running. J Biomech 47:3593-7
Farris, Dominic James; Hicks, Jennifer L; Delp, Scott L et al. (2014) Musculoskeletal modelling deconstructs the paradoxical effects of elastic ankle exoskeletons on plantar-flexor mechanics and energetics during hopping. J Exp Biol 217:4018-28
Hamner, Samuel R; Seth, Ajay; Steele, Katherine M et al. (2013) A rolling constraint reproduces ground reaction forces and moments in dynamic simulations of walking, running, and crouch gait. J Biomech 46:1772-6
Bruijn, Sjoerd M; Millard, Matthew; van Gestel, Leen et al. (2013) Gait stability in children with Cerebral Palsy. Res Dev Disabil 34:1689-99
Millard, Matthew; Uchida, Thomas; Seth, Ajay et al. (2013) Flexing computational muscle: modeling and simulation of musculotendon dynamics. J Biomech Eng 135:021005
Arnold, Edith M; Hamner, Samuel R; Seth, Ajay et al. (2013) How muscle fiber lengths and velocities affect muscle force generation as humans walk and run at different speeds. J Exp Biol 216:2150-60
Hamner, Samuel R; Delp, Scott L (2013) Muscle contributions to fore-aft and vertical body mass center accelerations over a range of running speeds. J Biomech 46:780-7
Steele, Katherine M; Demers, Matthew S; Schwartz, Michael H et al. (2012) Compressive tibiofemoral force during crouch gait. Gait Posture 35:556-60

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