This application describes a Research Network aimed at conceptual and methodological advances in understanding affect dysregulation in adolescence. The central theme for this project is the development and refinement of measures of affect regulation that can be used to investigate neurobehavioral systems in adolescents within a developmental framework. These include tasks that can be used in functional MRI and ERP (event-related potential) studies to examine the development of neurobehavioral systems in both clinical and normative populations of adolescents. It is also important to devise experimental paradigms that address clinically relevant and ecologically valid aspects of emotion and its regulation. This will require developing better conceptual models and formulating specific hypotheses about affective changes in developmental pathways of emotional disorders in adolescence. The long-term goals of this work are to address clinically relevant questions-to identify developmental pathways and mechanisms of affect dysregulation that can inform treatment strategies for early-onset depression, anxiety, and other emotional disorders emerging in adolescence. We focus on adolescence because this developmental phase represents a period of increased vulnerabilities for emotional disorders, yet also presents opportunities for early intervention. Ultimately, mechanistic understanding of the development of affect regulation can lead to prevention strategies targeting high-risk populations prior to the onset of more serious emotional disorders. A deeper understanding of affect regulation in adolescence may also provide insights into behaviors such as increased sensation seeking, risk-taking, and substance use-common behaviors in adolescence that can lead to serious consequences.
The specific aims of this research network are: (1) To develop and refine fMRI and ERP tasks of emotion regulation that can be used in clinical and developmental studies of older children and adolescents. (2) To develop and refine behavioral and experience-sampling methods of assessing emotion and its regulation in the natural environments of adolescents. (3) To improve heuristic models of affect regulation and dysregulation during adolescent development within a cognitive/affective neuroscience framework. (4) To provide outstanding interdisciplinary training experiences for young investigators. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Resource-Related Research Projects (R24)
Project #
5R24MH067346-03
Application #
6779064
Study Section
Special Emphasis Panel (ZMH1-CRB-J (01))
Program Officer
Delcarmen-Wiggins, Rebecca
Project Start
2002-09-23
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2005-06-30
Support Year
3
Fiscal Year
2004
Total Cost
$371,250
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Tan, Patricia Z; Silk, Jennifer S; Dahl, Ronald E et al. (2018) Age-Related Developmental and Individual Differences in the Influence of Social and Non-social Distractors on Cognitive Performance. Front Psychol 9:863
Dagys, Natasha; McGlinchey, Eleanor L; Talbot, Lisa S et al. (2012) Double trouble? The effects of sleep deprivation and chronotype on adolescent affect. J Child Psychol Psychiatry 53:660-7
McGlinchey, Eleanor L; Talbot, Lisa S; Chang, Keng-Hao et al. (2011) The effect of sleep deprivation on vocal expression of emotion in adolescents and adults. Sleep 34:1233-41
Stroud, Laura R; Papandonatos, George D; Williamson, Douglas E et al. (2011) Sex differences in cortisol response to corticotropin releasing hormone challenge over puberty: Pittsburgh Pediatric Neurobehavioral Studies. Psychoneuroendocrinology 36:1226-38
Mitchell, Amanda C; Aldridge, Georgina; Kohler, Shawn et al. (2010) Molecular correlates of spontaneous activity in non-human primates. J Neural Transm (Vienna) 117:1353-8
Ladouceur, Cecile D; Conway, Anne; Dahl, Ronald E (2010) Attentional control moderates relations between negative affect and neural correlates of action monitoring in adolescence. Dev Neuropsychol 35:194-211
Talbot, Lisa S; McGlinchey, Eleanor L; Kaplan, Katherine A et al. (2010) Sleep deprivation in adolescents and adults: changes in affect. Emotion 10:831-41
Sullivan, Elinor L; Cameron, Judy L (2010) A rapidly occurring compensatory decrease in physical activity counteracts diet-induced weight loss in female monkeys. Am J Physiol Regul Integr Comp Physiol 298:R1068-74
Forbes, Erika E; Hariri, Ahmad R; Martin, Samantha L et al. (2009) Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. Am J Psychiatry 166:64-73
Silk, Jennifer S; Siegle, Greg J; Whalen, Diana J et al. (2009) Pubertal changes in emotional information processing: pupillary, behavioral, and subjective evidence during emotional word identification. Dev Psychopathol 21:7-26

Showing the most recent 10 out of 26 publications