We propose to establish the Molecular biology Information Resource (MBIR), a regional resource for the Texas Medical Center (TMC) area, which will provide convenient and cost-efficient access to scientific databases and associated software tools to the resource participants. The resource will provide services to the participants in the form of specialized software for use on distributed processors (workstations), customized programming, access to centralized databases and specialized equipment. The resource staff will prepare documentation and manuals and will conduct workshops to train users to efficiently use the resource. The resource staff will be continually developing new capabilities of the system in response to the constantly changing nature of molecular biology research. The long-term goal of the MBIR is to establish a research support system that will continually evolve in response to developments in both computer technology and molecular biology, and that will provide state-of-the-art computer tools and education to the resource users. The availability of this resource is expected to have a significant impact on the conduct of molecular biology research in our research community.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Resource-Related Research Projects (R24)
Project #
5R24RR002581-02
Application #
3450639
Study Section
(SSS)
Project Start
1985-09-30
Project End
1988-09-29
Budget Start
1986-09-30
Budget End
1987-09-29
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Type
Schools of Medicine
DUNS #
074615394
City
Houston
State
TX
Country
United States
Zip Code
77030
Kobayashi, K; Jackson, M J; Tick, D B et al. (1990) Heterogeneity of mutations in argininosuccinate synthetase causing human citrullinemia. J Biol Chem 265:11361-7
Timme, T L; Lawrence, C B; Moses, R E (1989) Two new members of the OmpR superfamily detected by homology to a sensor-binding core domain. J Mol Evol 28:545-52
Jackson, M J; Kobayashi, K; Beaudet, A L et al. (1989) Analysis of deletions at the human argininosuccinate synthetase locus. Mol Biol Med 6:179-86
Fong, S L; Bridges, C D (1988) Internal quadruplication in the structure of human interstitial retinol-binding protein deduced from its cloned cDNA. J Biol Chem 263:15330-4
Lawrence, C B; Goldman, D A (1988) Definition and identification of homology domains. Comput Appl Biosci 4:25-33
Smith, V L; Doyle, K E; Maune, J F et al. (1987) Structure and sequence of the Drosophila melanogaster calmodulin gene. J Mol Biol 196:471-85
Anderson, R S; Lawrence, C B; Wilson, S H et al. (1987) Genetic relatedness of human DNA polymerase beta and terminal deoxynucleotidyltransferase. Gene 60:163-73
Jahnsen, T; Hedin, L; Kidd, V J et al. (1986) Molecular cloning, cDNA structure, and regulation of the regulatory subunit of type II cAMP-dependent protein kinase from rat ovarian granulosa cells. J Biol Chem 261:12352-61
Lawrence, C B; Goldman, D A; Hood, R T (1986) Optimized homology searches of the gene and protein sequence data banks. Bull Math Biol 48:569-83