We are requesting a continuation of R25 CA089017, Multidisciplinary Training in Image-guided Therapy (IGT) at the Brigham and Women's Hospital. As we close in on the end of the second cycle, we are eager to continue on a successful track record in training MD and PhD fellows in the principles and practices of image-guided therapy for the treatment of cancer and cancer- related illnesses. To this end, we have prepared an application that has retained the most successful features of the training program that includes the most recent research occurring within the National Center for Image Guided Therapy (www.ncigt.org) (P41 EB015898, previously P41 RR019703) as well as in other relevant areas of the hospital community. The NCIGT provides a unique centralized infrastructure for clinical investigators, biomedical engineers, and basic scientists in promoting and advancing IGT methods and related clinical applications primarily aimed at the detection, diagnosis, and treatment of cancer. Fellows have the NCIGT efforts and new innovative technologies made available to them through seven training units: 1) Imaging;2) Computation;3) Tumor Ablation;4) Focused Ultrasound;5) Image-guided Neurosurgery;6) Image-guided Prostate Therapy;and 7) the Advanced Multimodality Image-Guided Operating (AMIGO) suite. The AMIGO, which is our new operating suite at the Brigham devoted to image-guided therapy, is a main area for Fellows to receive education and training and to initiate and complete cancer-focused research projects. At the outset of this two-year fellowship, trainees work with the PI, the Director of Education, and a senior faculty member/mentor to tailor an educational program that best meets the individual's needs and career goals. Fellows are exposed to both a specialized and a didactic curriculum, while concentrating on a specific area of cancer research. Additional mentors are assigned according to "Individual Training Plans." While each training program is unique, all fellows are required to engage in a research project of considerable duration and produce a "mock" or a real NIH grant application that is evaluated and reviewing internally. The PI, Advisory Committee, senior mentors, and other mentors, (depending on the research topic), take part in these reviews. The PI and Advisory Committee also provide oversight and strategic planning by 1) developing and refining a general recruitment plan and one targeted for underserved populations and women;2) assessing curriculum design and content;3) identifying trends in IGT research and training;and 4) making recommendations on the selection of fellows and placement in the program.

Public Health Relevance

This educational grant (R25 CA089017), the Multidisciplinary Training in Image-guided Therapy (IGT) at the Brigham and Women's Hospital, also known as the Image-Guided Therapy Fellowship, provides a unique program to allow for the expansion and learning of image guided therapy of cancer for the broad healthcare community. Image-guided therapy of cancer requires the training of medical doctors and scientists, who can work with the complex advanced technology that can diagnose, localize and treat tumors in the same clinical setting. By providing multidisciplinary training to many different individuals, we can expand the pool of experts with new treatment modalities in IGT across other centers and various clinical settings.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA089017-12
Application #
8695299
Study Section
Subcommittee G - Education (NCI)
Program Officer
Perkins, Susan N
Project Start
2000-12-01
Project End
2018-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
12
Fiscal Year
2014
Total Cost
$518,296
Indirect Cost
$38,392
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Ciris, Pelin Aksit; Cheng, Cheng-Chieh; Mei, Chang-Sheng et al. (2016) Dual-Pathway sequences for MR thermometry: When and where to use them. Magn Reson Med :
Torcuator, Roy G; Hulou, M Maher; Chavakula, Vamsidhar et al. (2016) Intraoperative real-time MRI-guided stereotactic biopsy followed by laser thermal ablation for progressive brain metastases after radiosurgery. J Clin Neurosci 24:68-73
Dolati, Parviz; Eichberg, Daniel; Golby, Alexandra et al. (2016) Multimodal Navigation in Endoscopic Transsphenoidal Resection of Pituitary Tumors Using Image-Based Vascular and Cranial Nerve Segmentation: A Prospective Validation Study. World Neurosurg 95:406-413
Gombos, Eva C; Jayender, Jagadeesan; Richman, Danielle M et al. (2016) Intraoperative Supine Breast MR Imaging to Quantify Tumor Deformation and Detection of Residual Breast Cancer: Preliminary Results. Radiology 281:720-729
Fischer, Krisztina; Meral, F Can; Zhang, Yongzhi et al. (2016) High-resolution renal perfusion mapping using contrast-enhanced ultrasonography in ischemia-reperfusion injury monitors changes in renal microperfusion. Kidney Int 89:1388-98
Glazer, Daniel I; Hassanzadeh, Elmira; Fedorov, Andriy et al. (2016) Diffusion-weighted endorectal MR imaging at 3T for prostate cancer: correlation with tumor cell density and percentage Gleason pattern on whole mount pathology. Abdom Radiol (NY) :
Golshan, Mehra; Losk, Katya; Mallory, Melissa A et al. (2016) Implementation of a Breast/Reconstruction Surgery Coordinator to Reduce Preoperative Delays for Patients Undergoing Mastectomy With Immediate Reconstruction. J Oncol Pract 12:e338-43
Mallory, Melissa Anne; Losk, Katya; Camuso, Kristen et al. (2016) Does "Two is Better Than One" Apply to Surgeons? Comparing Single-Surgeon Versus Co-surgeon Bilateral Mastectomies. Ann Surg Oncol 23:1111-6
Ciris, Pelin Aksit; Balasubramanian, Mukund; Seethamraju, Ravi T et al. (2016) Characterization of gradient echo signal decays in healthy and cancerous prostate at 3T improves with a Gaussian augmentation of the mono-exponential (GAME) model. NMR Biomed 29:999-1009
Sagara, Yasuaki; Freedman, Rachel A; Vaz-Luis, Ines et al. (2016) Patient Prognostic Score and Associations With Survival Improvement Offered by Radiotherapy After Breast-Conserving Surgery for Ductal Carcinoma In Situ: A Population-Based Longitudinal Cohort Study. J Clin Oncol 34:1190-6

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