This application seeks support for the renewal of a post-doctoral training program in Basic and Translational Imaging of Cancer at Vanderbilt University and Meharry Medical College. In vivo biomedical imaging has developed into a compendium of powerful techniques useful not only for the study of fundamental biological processes at the molecular level but also for patient care. Unfortunately, while there has been a steady increase in both the quality and quantity of imaging metrics that report on tumor status, these methods have not been moved effectively to clinical use. Thus, there is a critical need for scientists working at the interface of imaging and cancer biology/oncology to be trained in making the connections between imaging and basic molecular processes in cancer and then translating this knowledge into clinical practice. We propose to address this need with a comprehensive educational and research training program designed for 6 outstanding post-doctoral scientists. We will recruit trainees who have recently completed a graduate degree in a relevant area (particularly in Medicine, Biomedical Engineering, Physics, Chemistry, Molecular Biophysics, or Biology) who will pursue research focused on the basic and/or translational aspects of quantitative imaging of cancer. The didactic component of the proposed program will consist of seminars, relevant journal clubs, and the opportunity to take/audit a number of appropriate courses. The limited coursework will be organized so that those whose prior training emphasized the physical sciences can be trained in relevant aspects of biology/oncology and vice-versa so that all trainees, regardless of previous training, will be equipped with the necessary background to combine quantitative imaging and cancer biology/oncology at the highest levels. For the laboratory component, each trainee will have two mentors representing the disciplines of imaging science and cancer biology and/or oncology. All trainees will be mentored in the ethics of biomedical research as well as in grant writing. Trainees will be integrated into ongoing NIH funded studies within a leading biomedical imaging institute with strong connections to a leading cancer center. By combining the resources and programs of the Vanderbilt University Institute of Imaging Science, the Vanderbilt-Ingram Cancer Center, and the Cancer Center at Meharry Medical College, we believe we have outstanding infrastructure and personnel to focus and continue our exemplary training program in basic and translational imaging of cancer.

Public Health Relevance

This application seeks support for the renewal of post-doctoral training program in Multidisciplinary Training in Basic and Translational Cancer Imaging at Vanderbilt University and Meharry Medical College. In vivo biomedical imaging has developed from early uses of X-rays for diagnosis into a compendium of powerful techniques useful not only for patient care but also for the study of fundamental biological processes at the cellular and molecular levels. There is a critical need for scientists working at the interface of the physical and biological sciences to be trained in the ability to make the connections between imaging and basic biological processes in cancer and then translate these insights into clinical care. This program is aimed at addressing this need.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA092043-14
Application #
8700127
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Perkins, Susan N
Project Start
2001-07-16
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
14
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
City
Nashville
State
TN
Country
United States
Zip Code
37212
Sorace, Anna G; Quarles, C Chad; Whisenant, Jennifer G et al. (2016) Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results. Breast Cancer Res Treat 155:273-84
Skinner, J T; Moots, P L; Ayers, G D et al. (2016) On the Use of DSC-MRI for Measuring Vascular Permeability. AJNR Am J Neuroradiol 37:80-7
Abramson, Richard G; Arlinghaus, Lori R; Dula, Adrienne N et al. (2016) MR Imaging Biomarkers in Oncology Clinical Trials. Magn Reson Imaging Clin N Am 24:11-29
Simmons, Alan J; Scurrah, Cherié R; McKinley, Eliot T et al. (2016) Impaired coordination between signaling pathways is revealed in human colorectal cancer using single-cell mass cytometry of archival tissue blocks. Sci Signal 9:rs11
Simmons, Alan J; Banerjee, Amrita; McKinley, Eliot T et al. (2015) Cytometry-based single-cell analysis of intact epithelial signaling reveals MAPK activation divergent from TNF-α-induced apoptosis in vivo. Mol Syst Biol 11:835
Barnes, Stephanie L; Sorace, Anna G; Loveless, Mary E et al. (2015) Correlation of tumor characteristics derived from DCE-MRI and DW-MRI with histology in murine models of breast cancer. NMR Biomed 28:1345-56
Cheung, Yiu-Yin; Nickels, Michael L; McKinley, Eliot T et al. (2015) High-yielding, automated production of 3'-deoxy-3'-[(18)F]fluorothymidine using a modified Bioscan Coincidence FDG reaction module. Appl Radiat Isot 97:47-51
Sengupta, Saikat; Smith, David S; Welch, E Brian (2015) Continuously moving table MRI with golden angle radial sampling. Magn Reson Med 74:1690-7
McKinley, Eliot T; Watchmaker, Jennifer M; Chakravarthy, A Bapsi et al. (2015) [(18)F]-FLT PET to predict early response to neoadjuvant therapy in KRAS wild-type rectal cancer: a pilot study. Ann Nucl Med 29:535-42
Samuelson, Lynn E; Scherer, Randy L; VanSaun, Michael N et al. (2015) New tools for the quantitative assessment of prodrug delivery and neurotoxicity. Neurotoxicology 47:88-98

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