The UCLA scholars in Oncologic Molecular Imaging (SOMI) is a diverse training program bringing together 9 Departments, predominantly from the UCLA Life and Health Sciences, in order to train the next generation of molecular imaging scientist. Oncologic molecular imaging is a rapidly growing area which combines the disciplines of cell/molecular biology, chemistry, biomedical physics, biomathematics, pharmacology, imaging sciences, and clinical medicine to advance cancer research, diagnosis and management. The UCLA Department of Molecular & Medical Pharmacology (DMMP) and the Crump Institute for Molecular Imaging (CIMI) are key players in helping to move the field of molecular molecular imaging forward. With initial critical seed support from the UCLA Jonson Comprehensive Cancer Center (JCCC), UCLA has helped to rapidly grow the field of molecular imaging. Funding sources for the molecular imaging program at UCLA now include the Department of Energy, NCI (P50) In Vivo Cellular and Molecular Imigaing Center (ICMIC) grant, Several NCI R01'a, and NCI Small Animal Imaging Resource Program (SAIRP) grant. The time is ripe for training the next generation of scientists that can bridge the various fields needed to study cancer biology/therapeutics in intact living organisms. In the current proposal, our goals are to train 19 post-doctoral fellows through a diverse group of 29 basic science and clinical faculty mentors representing 7 program areas, 6 formal courses in molecular imaging, pharmacology, cancer biology, cancer immunology, virology, gene therapy, and clinical hematology/oncology rounds. Fellows will be recruited into a three year program and will complete coursework and research with at least two mentors. Furthermore, they will do a mock grant proposal in their third year to help them gain experience and confidence in the grant application process. Special attention will be given towards recruiting minority applicants. A Training Committee will carefully monitor the process of all SOMI trainees, and an Advisory Committee will monitor the entire SOMI program. Graduates of SOMI will be uniquely trained to study cancer in an organism context with state-of-the-art technologies. We are evolving area of the oncologic molecular imaging.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA098010-05
Application #
7290308
Study Section
Subcommittee G - Education (NCI)
Program Officer
Myrick, Dorkina C
Project Start
2003-09-12
Project End
2009-08-31
Budget Start
2007-09-26
Budget End
2009-08-31
Support Year
5
Fiscal Year
2007
Total Cost
$487,921
Indirect Cost
Name
University of California Los Angeles
Department
Pharmacology
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Kepe, Vladimir; Scafoglio, Claudio; Liu, Jie et al. (2018) Positron emission tomography of sodium glucose cotransport activity in high grade astrocytomas. J Neurooncol 138:557-569
Graham, Nicholas A; Minasyan, Aspram; Lomova, Anastasia et al. (2017) Recurrent patterns of DNA copy number alterations in tumors reflect metabolic selection pressures. Mol Syst Biol 13:914
Flores, Aimee; Schell, John; Krall, Abigail S et al. (2017) Lactate dehydrogenase activity drives hair follicle stem cell activation. Nat Cell Biol 19:1017-1026
Balandeh, Mehrdad; Waldmann, Christopher; Shirazi, Daniela et al. (2017) Electrochemical Fluorination and Radiofluorination of Methyl(phenylthio)acetate Using Tetrabutylammonium Fluoride (TBAF). J Electrochem Soc 164:G99-G103
Waldmann, Christopher M; Lebedev, Artem; Allison, Nathaniel et al. (2017) An automated synthesizer for electrochemical 18F-fluorination of organic compounds. Appl Radiat Isot 127:245-252
Le, Thuc M; Poddar, Soumya; Capri, Joseph R et al. (2017) ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways. Nat Commun 8:241
Freise, Amanda C; Zettlitz, Kirstin A; Salazar, Felix B et al. (2017) ImmunoPET Imaging of Murine CD4+ T Cells Using Anti-CD4 Cys-Diabody: Effects of Protein Dose on T Cell Function and Imaging. Mol Imaging Biol 19:599-609
Hong, Candice Sun; Graham, Nicholas A; Gu, Wen et al. (2016) MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4. Cell Rep 14:1590-1601
McCracken, M N; Tavaré, R; Witte, O N et al. (2016) Advances in PET Detection of the Antitumor T Cell Response. Adv Immunol 131:187-231
Tavaré, Richard; Escuin-Ordinas, Helena; Mok, Stephen et al. (2016) An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy. Cancer Res 76:73-82

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