The field of nanotechnology has excellent potential for developing innovative methods to diagnose cancer and provide improved methods for therapy. To fully exploit this new technology future researchers must receive multi-disciplinary training in cancer research and physical sciences/engineering. The mission of the Center for Cross Training Translational Cancer Researchers in Nanotechnology (CRIN) program is to provide cross-training to predoctoral students, postdoctoral scientists, and physicians in nanoscience, nanotechnology, and other emerging technologies, cancer biology, and translational research. Young scientists will be trained in nanoscience, nanoengineering, mesoscale engineering, and image recognition to cancer research. CRIN will build on existing cancer research programs, through the NCI designated UCSD Comprehensive Cancer Center, and nanotechnology focused research programs, including UCSD's Center of Cancer Nanotechnology Excellence and In vivo Cellular and Molecular Imaging Center. The faculty participants are successful researchers with over $27 million in research funding, and are experienced mentors. The program will support 5 graduate students and 2 post-doctoral fellows for two years each, and will provide new opportunities for training underrepresented minorities in cancer nanotechnology research. The program will include research based cross-training, didactic training, workshops, seminars, journal clubs, and professional development activities. CRIN will also develop outreach activities for clinicians, research scientists, and the community.

Public Health Relevance

Nanotechnology approaches hold great promise to produce novel diagnostics, imaging agents, and therapies for cancer. The proposed program will train multi-disciplinary researchers who will use advanced technologies to develop improved methods to diagnose and treat cancer patients.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
3R25CA153915-03S1
Application #
8497790
Study Section
Special Emphasis Panel (ZCA1-RTRB-2 (M1))
Program Officer
Lin, Alison J
Project Start
2010-09-03
Project End
2015-07-31
Budget Start
2012-08-01
Budget End
2013-07-31
Support Year
3
Fiscal Year
2012
Total Cost
$44,883
Indirect Cost
$1,907
Name
University of California San Diego
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Wang, Fei; Fang, Ronnie H; Luk, Brian T et al. (2016) Nanoparticle-Based Antivirulence Vaccine for the Management of Methicillin-Resistant Staphylococcus aureus Skin Infection. Adv Funct Mater 26:1628-1635
Luk, Brian T; Fang, Ronnie H; Hu, Che-Ming J et al. (2016) Safe and Immunocompatible Nanocarriers Cloaked in RBC Membranes for Drug Delivery to Treat Solid Tumors. Theranostics 6:1004-11
Schutt, Carolyn E; Ibsen, Stuart; Benchimol, Michael et al. (2015) Optical detection of harmonic oscillations in fluorescent dye-loaded microbubbles ensonified by ultrasound. Opt Lett 40:2834-7
Metildi, Cristina A; Felsen, Csilla N; Savariar, Elamprakash N et al. (2015) Ratiometric activatable cell-penetrating peptides label pancreatic cancer, enabling fluorescence-guided surgery, which reduces metastases and recurrence in orthotopic mouse models. Ann Surg Oncol 22:2082-7
Liberman, A; Wang, J; Lu, N et al. (2015) Mechanically Tunable Hollow Silica Ultrathin Nanoshells for Ultrasound Contrast Agents. Adv Funct Mater 25:4049-4057
Sandoval, Sergio; Mendez, Natalie; Alfaro, Jesus G et al. (2015) Quantification of endocytosis using a folate functionalized silica hollow nanoshell platform. J Biomed Opt 20:88003
Hu, Che-Ming J; Fang, Ronnie H; Wang, Kuei-Chun et al. (2015) Nanoparticle biointerfacing by platelet membrane cloaking. Nature 526:118-21
Ta, Casey N; Eghtedari, Mohammad; Mattrey, Robert F et al. (2014) 2-tier in-plane motion correction and out-of-plane motion filtering for contrast-enhanced ultrasound. Invest Radiol 49:707-19
Ibsen, Stuart; Shi, Guixin; Schutt, Carolyn et al. (2014) The behavior of lipid debris left on cell surfaces from microbubble based ultrasound molecular imaging. Ultrasonics 54:2090-8
Luk, Brian T; Hu, Che-Ming Jack; Fang, Ronnie H et al. (2014) Interfacial interactions between natural RBC membranes and synthetic polymeric nanoparticles. Nanoscale 6:2730-7

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