The University of Kentucky Cancer Nanotechnology Training Center (UK CNTC) will provide advanced multidisciplinary training for predoctoral students and postdoctoral fellows toward the goal of creating a new type of cancer researcher who is skilled and ready to pursue a career in cancer nanotechnology research. Nationally and internationally recognized faculty members at the University of Kentucky will collaborate to create a fertile environment for the novel exploration of nanotechnology and cancer. Expertise covers a broad multidisciplinary range of scientific areas in gastrointestinal cancer, lung cancer, gliomas, radiation medicine, surgery, cancer screening, imaging, and pharmacokinetics and dynamics. Among these faculty are 16 nanotechnology researchers in the Departments of Chemical Engineering, Materials Engineering, Electrical Engineering, Chemistry, and Pharmaceutical Sciences and 18 biomedical scientists or clinical oncologists in the Colleges of Pharmacy or Medicine. Based on existing research collaborations, we propose cancer nanotechnology projects composed of multidisciplinary focus area teams with the goal of training future leading researchers in the field of cancer nanotechnology in the following four areas: (1) early detection and diagnosis in lung, colon, and ovarian cancer;(2) treatment of gastrointestinal tumors and metastases;(3) lung cancer treatment;and (4) glioma therapy.
Specific Aim 1 is to expand the core expertise of participants in the UK CNTC through cross-disciplinary laboratory research training projects of up to two years involving innovative applications of nanotechnology to address specific unmet needs in cancer detection and therapy. Our trainees will be at the forefront of research that will be driven toward developing novel cancer therapies and diagnostic strategies based on nanotechnology. Through these activities, the trainees will obtain a detailed understanding of the molecular basis of cancer, the unresolved clinical problems in treating and diagnosing the disease, and acquire expertise in the field of nanotechnology.
In Specific Aim 2, the CNTC will provide trainees with problem-based and experiential training through seminars, workshops, short courses, clerkships, and laboratory training modules that will build their research skills and confidence as members of multi-disciplinary research teams. Each trainee will be immersed in individualized problem-based instruction and a broad multidisciplinary training through core courses, short courses, participation in seminars, undergraduate and early graduate student mentoring, and outreach activities designed to educate the public. Trainees will be guided through these programs with effective mentorship and an evaluation program (Specific Aim 3) that will assess the effectiveness of trainee progress and development. Finally, Specific Aim 4 is to highlight the accomplishments of CNTC trainees both regionally and nationally. As such, our trainees will learn to envision, articulate, and perform nanotechnology-centered research focused on developing novel solutions to the outstanding clinical problems associated with cancer.

Public Health Relevance

The University of Kentucky Cancer Nanotechnology Center will provide a systematic and unique multidisciplinary training environment, focusing on laboratory hands-on research, to create a workforce capable of using nanotechnology for solving intractable cancer research problems. Trainees of the Center will be immersed in a research environment designed to take advantage of the multiple research strengths of faculty at the University of Kentucky and will emerge with a broad yet detailed knowledge of cancer diagnostics, interventions, and related nanotechnology applications including drug delivery, early detection and treatment.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Education Projects (R25)
Project #
Application #
Study Section
Special Emphasis Panel (ZCA1-RTRB-2 (M1))
Program Officer
Grodzinski, Piotr
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Kentucky
Schools of Pharmacy
United States
Zip Code
Meenach, Samantha A; Tsoras, Alexandra N; McGarry, Ronald C et al. (2016) Development of three-dimensional lung multicellular spheroids in air- and liquid-interface culture for the evaluation of anticancer therapeutics. Int J Oncol 48:1701-9
Chan, Ryan; Sethi, Pallavi; Jyoti, Amar et al. (2016) Investigating the Radioresistant Properties of Lung Cancer Stem Cells in the Context of the Tumor Microenvironment. Radiat Res 185:169-81
Binzel, Daniel W; Shu, Yi; Li, Hui et al. (2016) Specific Delivery of MiRNA for High Efficient Inhibition of Prostate Cancer by RNA Nanotechnology. Mol Ther 24:1267-77
Binzel, Daniel W; Khisamutdinov, Emil; Vieweger, Mario et al. (2016) Mechanism of three-component collision to produce ultrastable pRNA three-way junction of Phi29 DNA-packaging motor by kinetic assessment. RNA 22:1710-1718
Dickerson, M; Howerton, B; Bae, Y et al. (2016) Light-Sensitive Ruthenium Complex-Loaded Cross-linked Polymeric Nanoassemblies for the Treatment of Cancer. J Mater Chem B Mater Biol Med 4:394-408
Lilly, Jacob L; Berron, Brad J (2016) The Role of Surface Receptor Density in Surface-Initiated Polymerizations for Cancer Cell Isolation. Langmuir 32:5681-9
Wydra, Robert J; Rychahou, Piotr G; Evers, B Mark et al. (2015) The role of ROS generation from magnetic nanoparticles in an alternating magnetic field on cytotoxicity. Acta Biomater 25:284-90
Jyoti, Amar; Fugit, Kyle D; Sethi, Pallavi et al. (2015) An in vitro assessment of liposomal topotecan simulating metronomic chemotherapy in combination with radiation in tumor-endothelial spheroids. Sci Rep 5:15236
Cahall, Calvin F; Lilly, Jacob L; Hirschowitz, Edward A et al. (2015) A Quantitative Perspective on Surface Marker Selection for the Isolation of Functional Tumor Cells. Breast Cancer (Auckl) 9:1-11
Wydra, Robert J; Oliver, Catherine E; Anderson, Kimberly W et al. (2015) Accelerated generation of free radicals by iron oxide nanoparticles in the presence of an alternating magnetic field. RSC Adv 5:18888-18893

Showing the most recent 10 out of 39 publications