Multidisciplinary training programs to prepare the next generation of pediatric cancer epidemiology and control researchers are urgently needed. We propose to establish a cross-institutional training program to address this underdeveloped area and provide future physician scientists the training opportunities required to develop their careers in pediatric oncology and childhood cancer epidemiologists. This training program will be under the umbrella of the Childhood Cancer Epidemiology and Prevention Center (CCEPC), a unique collaborative effort between Baylor College of Medicine/Texas Children's Hospital and The University of Texas MD Anderson Cancer Center (MDACC). The unique faculty strengths of these two neighbor institutions include pediatric oncology, molecular epidemiology, genomics, survivorship research, childhood obesity, statistics, and pharmacology, in the outstanding environment of the Texas Medical Center in Houston, provide the ideal setting for this training program. Our overall goal is to establish a multidisciplinary curriculum-driven training and career development program in Pediatric Cancer Epidemiology and Control (PCEC). We propose the following specific aims: 1. Recruit well qualified post-doctoral fellows (Ph.D.), and pediatric oncology clinical fellows (M.D. or M.D./Ph.D.) to receive specific mentored training (didactic and research experiences) in childhood cancer epidemiology and cancer prevention in a multi-disciplinary setting. We will also have a specific focus on recruiting quality minority applicants. 2. Develop a multidisciplinary curriculum that will provide a strong foundation in epidemiology, genetics, cancer biology, survivorship research, and cancer control. 3. Provide rich mentored research experiences for post-doctoral and clinical fellows. 4. Incorporate program evaluation and long-term tracking of trainees to assess efficacy of this training and career development program. 5. Provide career development mini-courses, seminars, and experiential activities for post-doctoral and clinical fellows to facilitate their transition from fellow to early-stage faculty member.

Public Health Relevance

We propose to establish a cross-institutional training program to prepare the next generation of pediatric cancer epidemiology and control researchers. The unique faculty strengths of these two neighbor institutions include pediatric oncology, molecular epidemiology, genomics, survivorship research, childhood obesity, statistics, and pharmacology, in the outstanding environment of the Texas Medical Center in Houston. This program will address the need and provide future physician scientists the training opportunities required to develop their careers in pediatric oncology and childhood cancer epidemiology and control.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Education Projects (R25)
Project #
5R25CA160078-04
Application #
8693605
Study Section
Subcommittee B - Comprehensiveness (NCI)
Program Officer
Perkins, Susan N
Project Start
2011-08-22
Project End
2016-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
4
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Baylor College of Medicine
Department
Pediatrics
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77030
Peckham-Gregory, Erin C; McClain, Kenneth L; Allen, Carl E et al. (2018) The role of parental and perinatal characteristics on Langerhans cell histiocytosis: characterizing increased risk among Hispanics. Ann Epidemiol 28:521-528
Chinn, Ivan K; Eckstein, Olive S; Peckham-Gregory, Erin C et al. (2018) Genetic and mechanistic diversity in pediatric hemophagocytic lymphohistiocytosis. Blood 132:89-100
Montealegre, J R; Peckham-Gregory, E C; Marquez-Do, D et al. (2018) Racial/ethnic differences in HPV 16/18 genotypes and integration status among women with a history of cytological abnormalities. Gynecol Oncol 148:357-362
Peckham-Gregory, Erin C; Danysh, Heather E; Brown, Austin L et al. (2017) Evaluation of maternal and perinatal characteristics on childhood lymphoma risk: A population-based case-control study. Pediatr Blood Cancer 64:
Peckham-Gregory, Erin C; Chakraborty, Rikhia; Scheurer, Michael E et al. (2017) A genome-wide association study of LCH identifies a variant in SMAD6 associated with susceptibility. Blood 130:2229-2232
Archer, Natalie P; Perez-Andreu, Virginia; Scheurer, Michael E et al. (2016) Family-based exome-wide assessment of maternal genetic effects on susceptibility to childhood B-cell acute lymphoblastic leukemia in hispanics. Cancer 122:3697-3704
Sankaran, Hari; Danysh, Heather E; Scheurer, Michael E et al. (2016) The Role of Childhood Infections and Immunizations on Childhood Rhabdomyosarcoma: A Report From the Children's Oncology Group. Pediatr Blood Cancer 63:1557-62
Banfield, Emilyn; Brown, Austin L; Peckham, Erin C et al. (2016) Exploratory analysis of ERCC2 DNA methylation in survival among pediatric medulloblastoma patients. Cancer Epidemiol 44:161-166
Brown, Austin L; Lupo, Philip J; Danysh, Heather E et al. (2016) Prevalence and Predictors of Overweight and Obesity Among a Multiethnic Population of Pediatric Acute Lymphoblastic Leukemia Survivors: A Cross-Sectional Assessment. J Pediatr Hematol Oncol 38:429-36
Brown, Austin L; Lupo, Philip J; Okcu, Mehmet Fatih et al. (2015) SOD2 genetic variant associated with treatment-related ototoxicity in cisplatin-treated pediatric medulloblastoma. Cancer Med 4:1679-86

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