A unique ten-week program is proposed for 10 students per summer for five years. The novel aspect of this research experience is to build off the successful joint computational and experimental NIH supported projects at Duquesne. The summer research program will be comprised of a computational workshop in which the students will be trained to use state-of-the- art software and hardware to solve biomedical problems. The remaining nine weeks will find the students in an experimental research laboratory working on a research project that incorporates computations. For example a student will be working in a medicinal chemists laboratory synthesizing new compounds that have been suggested based on docking calculations they had performed. Since all summer research projects will have theoretical and experimental components, the students will be expected to develop their student-professor communication skills with both the experimental and theoretical mentors.

Public Health Relevance

of this project to public health is in the training of future biomedical scientists. This project will provide an opportunity to undergraduate students from PUI and HBCU institutions that do not have strong undergraduate research program, especially in biomedical sciences, to participate in biomedical research.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Education Projects (R25)
Project #
5R25DA032519-04
Application #
8661729
Study Section
Special Emphasis Panel (ZDA1-GXM-A (16))
Program Officer
Hillery, Paul
Project Start
2011-08-01
Project End
2016-05-31
Budget Start
2014-06-01
Budget End
2015-05-31
Support Year
4
Fiscal Year
2014
Total Cost
$82,587
Indirect Cost
$6,118
Name
Duquesne University
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
004501193
City
Pittsburgh
State
PA
Country
United States
Zip Code
15282
Pulugulla, Sree H; Workman, Riley; Rutter, Nathan W et al. (2018) A combined computational and experimental approach reveals the structure of a C/EBP?-Spi1 interaction required for IL1B gene transcription. J Biol Chem 293:19942-19956
Galbraith, Madeline L; Madura, Jeffry D (2017) Identifying trends in hydration behavior for modifications to the hydrophobicity of poly(n-isopropylacrylamide). J Mol Graph Model 78:168-175
Herneisey, Michele; Williams, Jonathan; Mirtic, Janja et al. (2016) Development and characterization of resveratrol nanoemulsions carrying dual-imaging agents. Ther Deliv 7:795-808
Long, Caela C; Sadler, Katelyn E; Kolber, Benedict J (2016) Hormonal and molecular effects of restraint stress on formalin-induced pain-like behavior in male and female mice. Physiol Behav 165:278-85
Mountain, Gregory A; Jelier, Benson J; Bagia, Christina et al. (2014) Design and formulation of nanoemulsions using 2-(poly(hexafluoropropylene oxide)) perfluoropropyl benzene in combination with linear perfluoro(polyethylene glycol dimethyl ether). J Fluor Chem 162:38-44
Saunders, Matthew J; Liu, Wen; Szent-Gyorgyi, Christopher et al. (2013) Engineering fluorogen activating proteins into self-assembling materials. Bioconjug Chem 24:803-10