Abstract

Mayo Clinic Summer Undergraduate Research in Nephrology & Urology The Mayo Clinic has a rich history in both basic science and clinic science research in Nephrology & Urology, and has active PhD, MD and MD-PhD training programs. Annually, the Mayo Graduate School receives >1000 applications from Undergraduates to work with Mayo Clinic Investigators. The Mayo Clinic is home to both an O'Brien Urology Research Center as well as a Translational Polycystic Kidney Disease (PKD) Center. Both Mayo Centers are one of four NIH funded Centers in the US. For the past several years, both Centers have received supplemental funds to support summer undergraduate research related to kidney stones and PKD, respectively. This proposal, in response to RFA-DK-13-005 (R25) merges these two successful summer undergraduate programs into a more generalized Mayo Clinic Summer Undergraduate Research in Nephrology & Urology. Several students from Mayo's programs have entered PhD, MD, or MD- PhD programs, or have co-authored Nephrology or Urology-oriented peer-reviewed papers. Over the next 5 years, we proposed to fund 14 students/summer (70 students total) to work specifically with Mayo Investigators engaged in basic or translational research in Nephrology & Urology. This 5 year period will allow undergraduates in the program to perform innovative Nephrology & Urology research with leading Mayo Clinic research laboratories. Students will also participate in various educational programs (e.g., weekly seminars and mini-courses) to enhance their research experience. Their 10-week summer experience will culminate with (1) a 10-minute oral presentation of their work, (2) a Mayo-wide Summer Undergraduate poster presentation (> 120 student/yr) and (3) a NIDDK Summer Research Poster Symposium to be held annually in Bethesda, MD. Following the Summer Program, students will be academically tracked to determine the effectiveness of the Mayo Summer Undergraduate Research experience in Nephrology & Urology. Our goal is to increase the number of basic and clinical Nephrology & Urology researchers as a result of this training experience.

Public Health Relevance

The current proposal seeks to fund 14 undergraduate students annually to work with Mayo Clinic researchers in Nephrology or Urology. This 10-week summer program will pair undergraduates with Mayo Clinic researchers to carry out specific research projects. Additionally, students will participate in a research training course. Several mini-courses are available. Students will organize their lab data in to both an oral research presentation as well as a poster presentation. Posters will be presented at the Mayo-wide Summer Undergraduate Research Symposium (>120 students/y) as well as the NIDDK Summer Research Poster Symposium to be held annually in Bethesda, MD.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Education Projects (R25)
Project #
5R25DK101405-04
Application #
9256463
Study Section
Special Emphasis Panel (ZDK1-GRB-G (J3)S)
Program Officer
Rankin, Tracy L
Project Start
2014-04-01
Project End
2019-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
4
Fiscal Year
2017
Total Cost
$88,743
Indirect Cost
$6,573

  Institution

Name
Mayo Clinic, Rochester
Department
Type
Other Domestic Non-Profits
DUNS #
006471700
City
Rochester
State
MN
Country
United States
Zip Code
55905

  Publications

He, Kai; Ma, Xiaoyu; Xu, Tao et al. (2018) Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules. Nat Commun 9:3310
Hommos, Musab S; De Vriese, An S; Alexander, Mariam P et al. (2017) The Incidence of Primary vs Secondary Focal Segmental Glomerulosclerosis: A Clinicopathologic Study. Mayo Clin Proc 92:1772-1781
Ferrero, A; Gutjahr, R; Henning, A et al. (2017) Renal Stone Characterization using High Resolution Imaging Mode on a Photon Counting Detector CT System. Proc SPIE Int Soc Opt Eng 10132:
Eirin, Alfonso; Zhu, Xiang-Yang; Puranik, Amrutesh S et al. (2017) Mesenchymal stem cell-derived extracellular vesicles attenuate kidney inflammation. Kidney Int 92:114-124
Kashyap, Sonu; Warner, Gina; Hu, Zeng et al. (2017) Cardiovascular phenotype in Smad3 deficient mice with renovascular hypertension. PLoS One 12:e0187062
Landry, Greg M; Hirata, Taku; Anderson, Jacob B et al. (2016) Sulfate and thiosulfate inhibit oxalate transport via a dPrestin (Slc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. Am J Physiol Renal Physiol 310:F152-9
Haley, William E; Enders, Felicity T; Vaughan, Lisa E et al. (2016) Kidney Function After the First Kidney Stone Event. Mayo Clin Proc 91:1744-1752
Warner, Gina; Hein, Kyaw Zaw; Nin, Veronica et al. (2016) Food Restriction Ameliorates the Development of Polycystic Kidney Disease. J Am Soc Nephrol 27:1437-47
Tang, Xiaojing; Brown, Matthew R; Cogal, Andrea G et al. (2016) Functional and transport analyses of CLCN5 genetic changes identified in Dent disease patients. Physiol Rep 4:
Leng, Shuai; Huang, Alice; Cardona, Juan Montoya et al. (2016) Dual-Energy CT for Quantification of Urinary Stone Composition in Mixed Stones: A Phantom Study. AJR Am J Roentgenol 207:321-9

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