We seek continuation of the University of Kansas (KU) IMSD program, a program whose underrepresented scholars are enrolling in graduate programs in the sciences at more than twice the national average, and that has succeeded in bringing five American Indians into PhD programs. KU IMSD works in concert with other MORE programs (Bridge, PREP, RISE, IRACDA) and takes full advantage of the juxtaposition of a Research I Institution (KU) and one of the largest tribal colleges (Haskell Indian Nations University). KU IMSD consists of four components: 1) mentored research experiences for American Indian and other scholars currently underrepresented in the sciences, with a particular focus on recruiting scholars from the KU / Haskell Bridge program;2) enhancements to the science and math curriculum;3) IMSD seminar program and 4) providing mentoring (academic and career) and financial support. The undergraduate research experience takes a broad, interdisciplinary approach to placing IMSD scholars into one of 80 possible KU labs and requires students to share their research results at local and national meetings. KU's agreement to institutionalize curricular enhancements in core biology, chemistry, and math courses that were developed by our previous IMSD programs allows for continuation of these highly successful programs and the development of a new """"""""Transitions in Mathematics"""""""" course for transfer students. A mandatory five semester seminar series includes a responsible conduct of research course and a required application to graduate school. Wages for KU IMSD scholars conducting undergraduate research will be a cornerstone in providing financial support along with KU scholarships targeted for American Indian students. Mentoring will be provided by the faculty research mentor, the IMSD Program Coordinator (individual and group meetings) and peers (senior IMSD scholars). Evaluation of measurable objectives will be carried out by an external evaluator with the assistance of the internal evaluator. Evaluation and tracking procedures allow for regular adjustment of activities during the course of the program and assessment of whether goals have been met. Continuation of the KU IMSD will maintain the momentum established by these KU / Haskell collaborations and significantly impact the number of American Indian scientists in this country.

Public Health Relevance

- Relevance The proposed project will increase the diversity of the scientific community by preparing American Indians and other underrepresented students for graduate study and careers in biomedical research. The project will increase the size of the scientific workforce and increase interest in research regarding diseases with a high incidence in minority populations with the potential to improve both health care and disease prevention in this country.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Education Projects (R25)
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Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Janes, Daniel E
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University of Kansas Lawrence
Schools of Arts and Sciences
United States
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Grussendorf, Kelly A; Trezza, Christopher J; Salem, Alexander T et al. (2016) Facilitation of Endosomal Recycling by an IRG Protein Homolog Maintains Apical Tubule Structure in Caenorhabditis elegans. Genetics 203:1789-806
Park, Hyewon; Galbraith, Richard; Turner, Thaddeus et al. (2016) Loss of Ewing sarcoma EWS allele promotes tumorigenesis by inducing chromosomal instability in zebrafish. Sci Rep 6:32297
Mostafa, Heba H; van Loben Sels, Jessica M; Davido, David J (2015) Herpes simplex virus 1 upregulates p35, alters CDK-5 localization, and stimulates CDK-5 kinase activity during acute infection in neurons. J Virol 89:5171-5
Smith, Amber R; Marquez, Rebecca T; Tsao, Wei-Chung et al. (2015) Tumor suppressive microRNA-137 negatively regulates Musashi-1 and colorectal cancer progression. Oncotarget 6:12558-73
Singer, Benjamin D; Mock, Jason R; Aggarwal, Neil R et al. (2015) Regulatory T cell DNA methyltransferase inhibition accelerates resolution of lung inflammation. Am J Respir Cell Mol Biol 52:641-52
Rennerfeldt, Deena A; Renth, Amanda N; Talata, Zsolt et al. (2013) Tuning mechanical performance of poly(ethylene glycol) and agarose interpenetrating network hydrogels for cartilage tissue engineering. Biomaterials 34:8241-57
Koch, Jordan M; Holder, Mark T (2012) An algorithm for calculating the probability of classes of data patterns on a genealogy. PLoS Curr 4:e4fd1286980c08
Wacker, Michael J; Tevis, Oksana; Hanke, Justin et al. (2012) Characterization of thromboxane Aâ‚‚ receptor and TRPV1 mRNA expression in cultured sensory neurons. Neurosci Lett 515:12-7
Day, Timothy P; Sil, Diptesh; Shukla, Nikunj M et al. (2011) Imbuing aqueous solubility to amphotericin B and nystatin with a vitamin. Mol Pharm 8:297-301
Adediran, Samusi A; Day, Timothy P; Sil, Diptesh et al. (2009) Synthesis of a highly water-soluble derivative of amphotericin B with attenuated proinflammatory activity. Mol Pharm 6:1582-90

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