The number of underrepresented minority (URM) faculty in biomedical sciences is extremely low in comparison with other ethnic groups. This situation could be reversed with an increase in the population of URM graduate students and postdoctoral fellows. The overall objective of this application, in response to the Initiative for Maximizing Student Diversity (IMSD), is to channel undergraduate students into Ph.D. programs in the biomedical sciences. URM scholars will be engaged very early on in their undergraduate studies in hands-on bench research, first as part of a summer program, where they will be introduced to basic laboratory techniques and scientific thinking. This initial program is likely to increase the retention of URM students in the field of science (specific aim 1). After the summer program, these students will join the laboratories of well- established investigators who will serve as their mentors. These mentors will further train and motivate the scholars to pursue Ph.D. degrees. Participants will be assisted in their applications to various Ph.D. programs (specific aim 2). Scholars that achieve a minimum of requirements (a GPA of 3.0 or above, completion of a graduate course with a grade of B or better, and a strong recommendation from the student's mentor) will have guaranteed admission into the Biomedical Science (BMS) Ph.D. program at the University of California, San Diego (UCSD) where they will be supported for two years and aided in obtaining independent funding to complete their Ph.D. degrees. Moreover, these students will be educated on how to develop a strategy for obtaining faculty positions after postdoctoral training (specific aim 3). Since educators are highly influential role models and directly responsible for the learning experience, a wide ethnic pool of teachers is needed to guarantee the wealth in opinion and experience required for the desired well-rounded development of future American scientists. The number of underrepresented minority (URM) faculty in biomedical sciences is extremely low in comparison with other ethnic groups. This situation could be reversed with an increase in the population of URM Ph.D. students in biomedical sciences, which is the overall objective of this application.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Education Projects (R25)
Project #
Application #
Study Section
Minority Programs Review Committee (MPRC)
Program Officer
Singh, Shiva P
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Hoffmann, Hanne M; Trang, Crystal; Gong, Ping et al. (2016) Deletion of Vax1 from Gonadotropin-Releasing Hormone (GnRH) Neurons Abolishes GnRH Expression and Leads to Hypogonadism and Infertility. J Neurosci 36:3506-18
Lehmann, Jason S; Corey, Victoria C; Ricaldi, Jessica N et al. (2016) Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. Am J Trop Med Hyg 94:302-13
Williams, Michael R; Cauvi, David M; Rivera, Isabel et al. (2016) Changes in macrophage function modulated by the lipid environment. Innate Immun 22:141-51
Mirendil, H; Thomas, E A; De Loera, C et al. (2015) LPA signaling initiates schizophrenia-like brain and behavioral changes in a mouse model of prenatal brain hemorrhage. Transl Psychiatry 5:e541
NiƱo, Diego F; Cauvi, David M; De Maio, Antonio (2014) Itraconazole, a commonly used antifungal, inhibits Fc? receptor-mediated phagocytosis: alteration of Fc? receptor glycosylation and gene expression. Shock 42:52-9
Lehmann, Jason S; Matthias, Michael A; Vinetz, Joseph M et al. (2014) Leptospiral pathogenomics. Pathogens 3:280-308
Cauvi, David M; Williams, Michael R; Bermudez, Jose A et al. (2014) Elevated expression of IL-23/IL-17 pathway-related mediators correlates with exacerbation of pulmonary inflammation during polymicrobial sepsis. Shock 42:246-55
Armijo, Gabrielle; Okerblom, Jonathan; Cauvi, David M et al. (2014) Interaction of heat shock protein 70 with membranes depends on the lipid environment. Cell Stress Chaperones 19:877-86
Agampodi, Suneth B; Moreno, Angelo C; Vinetz, Joseph M et al. (2013) Utility and limitations of direct multi-locus sequence typing on qPCR-positive blood to determine infecting Leptospira strain. Am J Trop Med Hyg 88:184-5
Lin, Huilan; Liu, Allen P; Smith, Thomas H et al. (2013) Cofactoring and dimerization of proteinase-activated receptors. Pharmacol Rev 65:1198-213

Showing the most recent 10 out of 22 publications