Abstract

Despite the disproportionate burden of cardiovascular diseases in urban minority populations, the number of underrepresented minorities participating in biomedical research and the health-related sciences is alarmingly low - Blacks account for less than 3% of those engaged in biomedical research. Although African Americans, Hispanics, and Native Americans make up 24% of the U.S. population and graduate from high school at rates closer to those of whites, they receive only 7% of science and engineering PhDs. The overall goal of this proposal is to develop programs/activities that will enhance research capacity building at Texas Southern University (TSU), promote increased intensive laboratory training to students, and add to the number of minority biomedical scientists that conduct health disparities research.
The Specific Aims of this competitive renewal application are to: 1. Provide support for investigators to obtain independent research grants 2. Provide intensive laboratory training to students and increase the quality of biomedical graduate education 3. Strengthen science faculty and enhance biomedical research capability and capacity of TSU. This application proposes to increase the biomedical research portfolio at TSU and provide enhanced training in the biomedical sciences for investigators and faculty, postdoctoral fellows/research associates, graduate and undergraduate students through the following activities: 1) additional research grants; 2) intensive laboratory training; 3) active participation in seminars, journal clubs, and laboratory meetings; 4) organization of research, educational, and career workshops; and, 5) collaboration with other scientists. It is hoped that this proposal will enhance the biomedical research profile of TSU, assist more investigators and faculty in seeking and obtaining independent research grants, and increase the number of minority students seeking graduate education in biomedical sciences and the quality of education they receive. ? ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Education Projects (R25)
Project #
5R25HL003674-09
Application #
7293523
Study Section
Special Emphasis Panel (ZHL1-CSR-G (M2))
Program Officer
Paltoo, Dina
Project Start
1996-09-30
Project End
2011-08-31
Budget Start
2007-09-01
Budget End
2008-08-31
Support Year
9
Fiscal Year
2007
Total Cost
$417,142
Indirect Cost

  Institution

Name
Texas Southern University
Department
Type
Other Domestic Higher Education
DUNS #
050298975
City
Houston
State
TX
Country
United States
Zip Code
77004

  Publications

Oyagbemi, Ademola Adetokunbo; Omobowale, Temidayo Olutayo; Adedapo, Adeolu Alex et al. (2016) Kolaviron, Biflavonoid Complex from the Seed of Garcinia kola Attenuated Angiotensin II- and Lypopolysaccharide-induced Vascular Smooth Muscle Cell Proliferation and Nitric Oxide Production. Pharmacognosy Res 8:S50-5
Dallatu, Mohammad K; Nwokocha, Elizabeth; Agu, Ngozi et al. (2014) The Role of Hypoxia-Inducible Factor/Prolyl Hydroxylation Pathway in Deoxycorticosterone Acetate/Salt Hypertension in the Rat. J Hypertens (Los Angel) 3:
Rizvi, Yasmeen Q; Mehta, Chander S; Oyekan, Adebayo (2013) Interactions of PPAR-alpha and adenosine receptors in hypoxia-induced angiogenesis. Vascul Pharmacol 59:144-51
Yakubu, Momoh A; Nsaif, Rami H; Oyekan, Adebayo O (2010) Regulation of cerebrovascular endothelial peroxisome proliferator activator receptor alpha expression and nitric oxide production by clofibrate. Bratisl Lek Listy 111:258-64
Yousefipour, Zivar; Oyekan, Adebayo; Newaz, Mohammad (2009) Role of G protein-coupled receptor kinase-2 in peroxisome proliferator-activated receptor gamma-mediated modulation of blood pressure and renal vascular reactivity in SHR. Am J Nephrol 30:201-8
Yakubu, Momoh A; Nsaif, Rami H; Oyekan, Adebayo O (2007) peroxisome proliferator-activated receptor alpha activation-mediated regulation of endothelin-1 production via nitric oxide and protein kinase C signaling pathways in piglet cerebral microvascular endothelial cell culture. J Pharmacol Exp Ther 320:774-81
Newaz, Mohammad; Yousefipour, Zivar; Oyekan, Adebayo (2006) Role of PPAR-gamma on the pathogenesis and vascular changes in glycerol-induced acute renal failure. Pharmacol Res 54:234-40
Newaz, Mohammad A; Yousefipour, Zivar; Oyekan, Adebayo (2006) Oxidative stress-associated vascular aging is xanthine oxidase-dependent but not NAD(P)H oxidase-dependent. J Cardiovasc Pharmacol 48:88-94
Ajayi, A A; Ogungbade, G O; Hercule, H C et al. (2004) Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats. Diabetes Res Clin Pract 63:155-69
Newaz, Mohammad A; Ranganna, Kasturi; Oyekan, Adebayo O (2004) Relationship between PPARalpha activation and NO on proximal tubular Na+ transport in the rat. BMC Pharmacol 4:1

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