The objective of the program is to provide undergraduate students and research- oriented medical students from diverse, underrepresented backgrounds with a short- term, intensive biomedical laboratory research experience for 8-10 weeks during the summer at the University of Pennsylvania. The long-term aim of the program is to increase the pool of underrepresented students committed to careers in cardiovascular, pulmonary, and hematologic research. Training is provided by a core group of 51 trainers who have extensive experience as mentors to trainees at all levels and whose research interests relate to aspects of the heart, lung, and blood, as well as by a secondary group of more than 50 additional prospective mentors who conduct NHLBI sponsored research. Each trainee devotes approximately 90% of his or her time to hands-on laboratory research, experimental design, data interpretation, directed readings, lab meetings, and journal clubs. Trainees participate in a scientific seminar series presented by University of Pennsylvania faculty, receive supplemental training in academically relevant areas, including scientific presentation skills and the responsible conduct of research, and are provided with a variety of optional peer-networking and career-development activities and workshops. Trainees present their work in at least one formal setting at the end of the program and are encouraged to continue their association with the laboratory;undergraduates may return for a second summer research experience. This proposal seeks to integrate training that was formerly provided separately, via two different NHLBI grants: R25-HL084665 (formerly T35- HL007719) was originally established in 1991 for research-oriented medical students in the School of Medicine at the University of Pennsylvania, and T35-HL007789 was established in 1993 for undergraduates from a geographically and culturally diverse array of colleges and universities who come to the University of Pennsylvania for the summer. It is expected that the integration of these programs will build on existing strengths and result in an enriched trainee experience.

Public Health Relevance

The NHLBI Short-Term Research Education Program to Increase Diversity in Health- Related Research at the University of Pennsylvania School of Medicine provides undergraduate students and research-oriented medical students from diverse, underrepresented backgrounds with a short-term, intensive summer research experience with the goal of increasing the pool of underrepresented students committed to careers in cardiovascular, pulmonary, and hematologic research.

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Education Projects (R25)
Project #
Application #
Study Section
Special Emphasis Panel (ZHL1-CSR-H (M2))
Program Officer
Chang, Henry
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pennsylvania
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Song, Delu; Kanu, Levi N; Li, Yafeng et al. (2016) AMD-like retinopathy associated with intravenous iron. Exp Eye Res 151:122-33
Silvestre, Jason; Chang, Benjamin; Serletti, Joseph M (2016) Relevancy of an In-Service Examination for Core Knowledge Training in a Surgical Subspecialty. J Surg Educ 73:305-10
Silvestre, Jason; Lin, Ines C; Chang, Benjamin et al. (2016) Unique Assessment of Hand Surgery Knowledge by Specialty. Plast Reconstr Surg 137:917-24
Silvestre, Jason; Chang, Benjamin; Taylor, Jesse A (2016) Analysis of an In-Service Examination for Core Pediatric Craniofacial Surgery Knowledge. J Surg Educ 73:375-80
Silvestre, Jason; Chang, Benjamin; Serletti, Joseph M (2016) The Plastic Surgery In-Service Training Exam for Board Preparation. Plast Reconstr Surg 137:260e-261e
Binenbaum, Gil; Christian, Cindy W; Guttmann, Katy et al. (2015) Evaluation of Temporal Association Between Vaccinations and Retinal Hemorrhage in Children. JAMA Ophthalmol 133:1261-5
Cielo, Christopher M; Silvestre, Jason; Paliga, J Thomas et al. (2014) Utility of screening for obstructive sleep apnea syndrome in children with craniofacial disorders. Plast Reconstr Surg 134:434e-441e
Silvestre, Jason; Tahiri, Youssef; Paliga, J Thomas et al. (2014) Screening for obstructive sleep apnea in children with syndromic cleft lip and/or palate. J Plast Reconstr Aesthet Surg 67:1475-80
Lavanya, Madakasira; Cuevas, Christian D; Thomas, Monica et al. (2013) siRNA screen for genes that affect Junín virus entry uncovers voltage-gated calcium channels as a therapeutic target. Sci Transl Med 5:204ra131
Keenan, Tanya E; Rader, Daniel J (2013) Genetics of lipid traits and relationship to coronary artery disease. Curr Cardiol Rep 15:396

Showing the most recent 10 out of 12 publications