This R25 application responds to the NIMH RFA, """"""""Training Future Mental Health Clinical Researchers,"""""""" and seeks to establish a new educational clinical research training program in psychiatric genetics. The overall aim of the proposed training program is to fill a gap in the post-doctoral training opportunities available in clinical research. Currently, it is difficult for a young scientist to acquire a focused training in psychiatric genetics. There are many excellent training programs that focus on components of the psychiatric genetics curriculum, but few that provide complete training in all areas of this discipline. The Executive Director of this training program has worked in the field of psychiatric genetics for over three decades, and has created an extensive research infrastructure that has brought together a variety of independent investigators who have long collaborated together in productive efforts to understand the genetic basis of psychiatric disorders. The training and development of new investigators has always been a cornerstone of our collective efforts. In this proposal, we seek to formalize our commitment to prepare future generations of independent researchers by creating a comprehensive, multidisciplinary post-doctoral training program to provide promising young mental health clinicians with the tools needed to pursue clinical research in psychiatric genetics. The goals of the program are: 1) To create a coherent didactic and experiential post-doctoral training program in psychiatric 2) To implement this training program using faculty from multiple disciplines: psychiatry, psychology, statistical genetics, molecular genetics, behavioral genetics, neuropsychology and neuroscience; and 3) To evaluate this program by assessing the ability of trainees to attain the following goals during their training: a) maintenance of a 3.5 grade point average in didactic courses; b) publication of two papers per year and c) submission and funding of a competitive grant application. Finally, we will seek to create a training infrastructure that will allow students to benefit from the rapid advances of science and technology on the one hand, and their ethical, legal and social consequences, on the other.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Education Projects (R25)
Project #
5R25MH060485-03
Application #
6392665
Study Section
Special Emphasis Panel (ZMH1-CRB-J (03))
Program Officer
Wynne, Debra K
Project Start
1999-09-23
Project End
2003-08-31
Budget Start
2001-09-01
Budget End
2002-08-31
Support Year
3
Fiscal Year
2001
Total Cost
$158,150
Indirect Cost
Name
Harvard University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Wilcox, James; Winokur, George; Tsuang, Ming (2012) Predictive value of thought disorder in new-onset psychosis. Compr Psychiatry 53:674-8
Thermenos, Heidi W; Goldstein, Jill M; Milanovic, Snezana M et al. (2010) An fMRI study of working memory in persons with bipolar disorder or at genetic risk for bipolar disorder. Am J Med Genet B Neuropsychiatr Genet 153B:120-31
Rosso, Isabelle M; Makris, Nikos; Thermenos, Heidi W et al. (2010) Regional prefrontal cortex gray matter volumes in youth at familial risk for schizophrenia from the Harvard Adolescent High Risk Study. Schizophr Res 123:15-21
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Takahashi, Sakae; Cui, Yu-hu; Han, Yong-hua et al. (2008) Association of SNPs and haplotypes in APOL1, 2 and 4 with schizophrenia. Schizophr Res 104:153-64
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Thermenos, Heidi W; Seidman, Larry J; Poldrack, Russell A et al. (2007) Elaborative verbal encoding and altered anterior parahippocampal activation in adolescents and young adults at genetic risk for schizophrenia using FMRI. Biol Psychiatry 61:564-74
Seidman, Larry J; Thermenos, Heidi W; Poldrack, Russell A et al. (2006) Altered brain activation in dorsolateral prefrontal cortex in adolescents and young adults at genetic risk for schizophrenia: an fMRI study of working memory. Schizophr Res 85:58-72
Glatt, Stephen J; Stone, William S; Faraone, Stephen V et al. (2006) Psychopathology, personality traits and social development of young first-degree relatives of patients with schizophrenia. Br J Psychiatry 189:337-45
Gamma, F; Faraone, Stephen V; Glatt, Stephen J et al. (2005) Meta-analysis shows schizophrenia is not associated with the 40-base-pair repeat polymorphism of the dopamine transporter gene. Schizophr Res 73:55-8

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