With the over-representation of racial and ethnic minority (REM) populations in HIV/AIDS, there is a need to recruit and mentor REM scientists involved in neuroAIDS investigations. The Mount Sinai Institute for NeuroAIDS Disparities (MSINAD) will stimulate entry and retention of REM and non-REM scientists working in the field of neuroAIDS disparities. This institute offers a multi-disciplinary curriculum spanning the fields of neurology, neuropsychology, psychiatry, neuropathology, and neuroscience. Selected scholars are given both didactic seminars and a research practicum;didactics cover both topics germaine to neuroAIDS disorders, and general tools for academic success, including grant development. Scholars are matched with both a scientific and a development mentor, and have access to a multi-disciplinary panel of senior scientists as well as junior faculty in AIDS disparities research as role models. By summer's end, scholars gain a strong grounding in topics necessary to conduct high quality, multi- disciplinary translational neuroAIDS research in REM communities. The MSINAD builds upon the infrastructures of two programs. The Manhattan HIV Brain Bank is a multi-disciplinary research resource that maintains an HIV-positive REM cohort that undergoes longitudinal neurologic, neuropsychologic, and psychiatric assessments. It routinely interacts with and supports a variety of neuroscientists investigating HIV manifestations and neuropathogenesis, has conducted pilot analyses of neuroAIDS disparities, and has successfully recruited and trained minority investigators who are entering the neuroAIDS research work force. The Mount Sinai Center for Multicultural and Community Affairs is a Center of Excellence for Minority Health, focused on reducing REM health outcome disparities by developing increased health care work force diversity, and providing support services at a variety of educational training and practice levels. Its Faculty Development Programs support minorities in a variety of research and clinical career pathways. By combining the unique strengths of these two programs, the MSINAD creates high quality, REM researchers whose long term careers will make a lasting contribution to the area of neuroAIDS disparities.

Public Health Relevance

As HIV/AIDS disproportionately impacts minority communities, it is imperative to generate a research workforce capable of investigating HIV-related nervous system disorders in culturally and scientifically appropriate manners. MSINAD has been created to recruit, train, mentor, and support the talents of young scientists interested in neuroAIDS disparities research, with a focus on REM investigators. MSINAD programs seek to improve the quality of research into neuroAIDS disorders.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Education Projects (R25)
Project #
5R25MH080663-05
Application #
8302248
Study Section
Special Emphasis Panel (ZMH1-ERB-S (03))
Program Officer
Stoff, David M
Project Start
2007-08-24
Project End
2016-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
5
Fiscal Year
2012
Total Cost
$270,000
Indirect Cost
$20,000
Name
Icahn School of Medicine at Mount Sinai
Department
Pathology
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029
Gutierrez, Jose; Menshawy, Khaled; Goldman, James et al. (2016) Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection. J Infect Dis 214:1329-1335
Gutierrez, Jose; Menshawy, Khaled; Gonzalez, Marco et al. (2016) Brain large artery inflammation associated with HIV and large artery remodeling. AIDS 30:415-23
Gutierrez, Jose; Honig, Lawrence; Elkind, Mitchell S V et al. (2016) Brain arterial aging and its relationship to Alzheimer dementia. Neurology 86:1507-15
Marquine, M J; Sakamoto, M; Dufour, C et al. (2016) The impact of ethnicity/race on the association between the Veterans Aging Cohort Study (VACS) Index and neurocognitive function among HIV-infected persons. J Neurovirol 22:442-54
Clark, Uraina S; Sweet, Lawrence H; Morgello, Susan et al. (2016) High early life stress and aberrant amygdala activity: risk factors for elevated neuropsychiatric symptoms in HIV+ adults. Brain Imaging Behav :
Alosco, Michael L; Gunstad, John; Beard, Courtney et al. (2015) The synergistic effects of anxiety and cerebral hypoperfusion on cognitive dysfunction in older adults with cardiovascular disease. J Geriatr Psychiatry Neurol 28:57-66
Clark, Uraina S; Walker, Keenan A; Cohen, Ronald A et al. (2015) Facial emotion recognition impairments are associated with brain volume abnormalities in individuals with HIV. Neuropsychologia 70:263-71
Thames, April D; Castellon, Steven A; Singer, Elyse J et al. (2015) Neuroimaging abnormalities, neurocognitive function, and fatigue in patients with hepatitis C. Neurol Neuroimmunol Neuroinflamm 2:e59
Sundermann, Erin E; Bishop, Jeffrey R; Rubin, Leah H et al. (2015) Genetic predictor of working memory and prefrontal function in women with HIV. J Neurovirol 21:81-91
Gutierrez, Jose; Goldman, James; Dwork, Andrew J et al. (2015) Brain arterial remodeling contribution to nonembolic brain infarcts in patients with HIV. Neurology 85:1139-45

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