Project Description: This proposal describes the Research Training Program for Neurology and Neurosurgery Residents at Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH) of Harvard Medical School (HMS). The program combines the exciting variety of collaborative research opportunities available at these campuses with a dedicated core group of neuroscience mentors. Mentors have been carefully selected by the PIs on the basis of research activity, experience guiding clinicians in the early stages of successful research careers, and commitment to this program to develop neurology and neurosurgery residents into effective physician-scientists. A steering committee has been meeting regularly during the creation of this application and will closely oversee all aspects of the resident research training experience.

Public Health Relevance

There is a widely recognized need for translational and clinical research in neurological diseases. Neurology and neurosurgery resident trainees are young physicians who are completing their clinical training and have first-hand knowledge of the limits of current technologies. Many of the residents at Massachusetts General Hospital and Brigham and Women's Hospitals of Harvard Medical School have extensive research backgrounds, and have expressed interest in neurological research. This application will link the tremendous depth and breadth of research resources available in the Harvard system to a small group of dedicated senior neuroscientists. These scientists are active researchers who have abundant experience training young physician researchers and who care deeply about the future of neurological research. These senior scientists will serve as mentors to guide the initial research experience of the neurology residents. A steering committee will help match residents and mentors and will monitor all aspects of the program's efficacy.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Education Projects (R25)
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Special Emphasis Panel (ZNS1-SRB-S (17))
Program Officer
Korn, Stephen J
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Massachusetts General Hospital
United States
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Kim, J A; Rosenthal, E S; Biswal, S et al. (2017) Epileptiform abnormalities predict delayed cerebral ischemia in subarachnoid hemorrhage. Clin Neurophysiol 128:1091-1099
Lam, Alice D; Maus, Douglas; Zafar, Sahar F et al. (2017) SCOPE-mTL: A non-invasive tool for identifying and lateralizing mesial temporal lobe seizures prior to scalp EEG ictal onset. Clin Neurophysiol 128:1647-1655
Chung, David Y; Mayer, Stephan A; Rordorf, Guy A (2017) External Ventricular Drains After Subarachnoid Hemorrhage: Is Less More? Neurocrit Care :
Liau, Brian B; Sievers, Cem; Donohue, Laura K et al. (2017) Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell 20:233-246.e7
Darby, R Ryan; Laganiere, Simon; Pascual-Leone, Alvaro et al. (2017) Finding the imposter: brain connectivity of lesions causing delusional misidentifications. Brain 140:497-507
Kelly, Michael S; Oliveira-Maia, Albino J; Bernstein, Margo et al. (2017) Initial Response to Transcranial Magnetic Stimulation Treatment for Depression Predicts Subsequent Response. J Neuropsychiatry Clin Neurosci 29:179-182
Chung, David Y; Leslie-Mazwi, Thabele M; Patel, Aman B et al. (2017) Management of External Ventricular Drains After Subarachnoid Hemorrhage: A Multi-Institutional Survey. Neurocrit Care 26:356-361
Choi, Bryan D; O'Rourke, Donald M; Maus, Marcela V (2017) Engineering Chimeric Antigen Receptor T cells to Treat Glioblastoma. J Target Ther Cancer 6:22-25
Bali, Taha; Self, Wade; Liu, Jingxia et al. (2017) Defining SOD1 ALS natural history to guide therapeutic clinical trial design. J Neurol Neurosurg Psychiatry 88:99-105
Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine et al. (2017) Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science 355:

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