This is a renewal proposal describing the Research Training Program for Neurology and Neurosurgery Residents at Massachusetts General Hospital (MGH) and Brigham and Women's Hospital (BWH) of Harvard Medical School (HMS). The program combines the exciting variety of collaborative research opportunities available at these campuses with a dedicated core group of neuroscience mentors aligned in a two tiered system which includes a 'gateway'mentor responsible for the overall career development of the R25 candidate and a 'research'mentor directly responsible for the scientific activities of the candidate. Mentors have been carefully selected on the basis of research activity, experience guiding clinicians in the early stages of successful research careers, and commitment to this program to develop neurology and neurosurgery residents into effective physician-scientists. In addition, a steering committee will closely oversee all aspects of the resident research training experience. This program has already had tremendous success in its first 5 years of funding which has included 23 trainees who have produced numerous high-impact first author publications and earned foundation as well as K12 and K23 funding. This programmatic structure builds on these successes to ensure that neurology and neurosurgical residents obtain the highest level of training possible to launch careers as outstanding physician-scientists.

Public Health Relevance

There is a widely recognized need for translational and clinical research in neurological diseases which can only be met by continuing to train new investigators who will bring innovative solutions to neurological health problems. This application looks to renew a successful program linking the tremendous depth and breadth of research resources available in the Harvard University system to a small group of dedicated senior neuroscientists mentors for the career development of residents.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Education Projects (R25)
Project #
2R25NS065743-06
Application #
8794737
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2009-03-04
Project End
2019-06-30
Budget Start
2014-09-01
Budget End
2015-06-30
Support Year
6
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Kim, J A; Rosenthal, E S; Biswal, S et al. (2017) Epileptiform abnormalities predict delayed cerebral ischemia in subarachnoid hemorrhage. Clin Neurophysiol 128:1091-1099
Lam, Alice D; Maus, Douglas; Zafar, Sahar F et al. (2017) SCOPE-mTL: A non-invasive tool for identifying and lateralizing mesial temporal lobe seizures prior to scalp EEG ictal onset. Clin Neurophysiol 128:1647-1655
Chung, David Y; Mayer, Stephan A; Rordorf, Guy A (2017) External Ventricular Drains After Subarachnoid Hemorrhage: Is Less More? Neurocrit Care :
Liau, Brian B; Sievers, Cem; Donohue, Laura K et al. (2017) Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. Cell Stem Cell 20:233-246.e7
Darby, R Ryan; Laganiere, Simon; Pascual-Leone, Alvaro et al. (2017) Finding the imposter: brain connectivity of lesions causing delusional misidentifications. Brain 140:497-507
Kelly, Michael S; Oliveira-Maia, Albino J; Bernstein, Margo et al. (2017) Initial Response to Transcranial Magnetic Stimulation Treatment for Depression Predicts Subsequent Response. J Neuropsychiatry Clin Neurosci 29:179-182
Chung, David Y; Leslie-Mazwi, Thabele M; Patel, Aman B et al. (2017) Management of External Ventricular Drains After Subarachnoid Hemorrhage: A Multi-Institutional Survey. Neurocrit Care 26:356-361
Choi, Bryan D; O'Rourke, Donald M; Maus, Marcela V (2017) Engineering Chimeric Antigen Receptor T cells to Treat Glioblastoma. J Target Ther Cancer 6:22-25
Bali, Taha; Self, Wade; Liu, Jingxia et al. (2017) Defining SOD1 ALS natural history to guide therapeutic clinical trial design. J Neurol Neurosurg Psychiatry 88:99-105
Venteicher, Andrew S; Tirosh, Itay; Hebert, Christine et al. (2017) Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq. Science 355:

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