This is a proposal for continuation of an R25 research education award at the University of Alabama at Birmingham (UAB). This program will support residents in neuroscience fields who are pursuing careers combining clinical practice and research, and foster their development as physician-scientists. Over the past two decades, considerable efforts and resources have been devoted to understanding nervous system function in health and disease, and the result has been a vast expansion of knowledge encompassing fundamental discoveries in genetics, genomics, neuro-oncology, neurochemistry, synaptic plasticity, neural development, and behavior. It is clear, however, that there remains an unmet gap between these advances and applications to human health. A pressing need for next-generation physician-scientists includes: i) integrate discoveries about the nervous system from several domains into multi-modal and multi- dimensional frameworks; and ii) formulate translational pathways to apply this knowledge to important biomedical and behavioral problems. The new and exciting initiatives in this renewal proposal are as follows: 1) Dr. David Standaert continues as Program Director, but he has been teamed with the new Associate Director, Dr. Ichiro Nakano; 2) the scope has been expanded and now includes not only neurology, neurosurgery, and neuropathology but also radiology and anesthesiology residents who are working areas consistent with the NINDS mission; 3) the mentors have been organized around the four themes, that is, neuro-oncology, neurodegeneration, synaptic plasticity, and cerebrovascular disease; 4) didactic components are strengthened, including a formal course in experimental rigor. The Program Director and Associate Director are both physician-scientists with established track records in research and training. Residents supported by this program will initiate their research during their residency training, and continue it into a period of research fellowship following residency. Participants from all disciplines will engage in a total of two years in full time research training. Their research experience will be supported by a structured mentoring program along with didactic teaching in experimental rigor, professional skills training, grant writing, and responsible conduct of research. The goal of the program will be to enable residents and fellows to develop a career in neurological research, and to prepare them to successfully compete for individual fellowships or mentored career development awards. As an institution, UAB is exceptionally well positioned to undertake research education in the neurosciences, and to develop the physician-scientists who will apply today?s discoveries to solve the challenges of tomorrow.

Public Health Relevance

Diseases of the nervous system create a great burden on our citizens and society, and there is a critical need for new treatments and cures. This research education program will educate physician-scientists at the early stages of their training, and provide them with the knowledge needed to address these important public health problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Education Projects (R25)
Project #
2R25NS079188-06
Application #
9208982
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2012-07-01
Project End
2022-06-30
Budget Start
2017-08-01
Budget End
2018-06-30
Support Year
6
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Neurology
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Espay, Alberto J; Schwarzschild, Michael A; Tanner, Caroline M et al. (2017) Biomarker-driven phenotyping in Parkinson's disease: A translational missing link in disease-modifying clinical trials. Mov Disord 32:319-324
Gerstenecker, Adam; Roberson, Erik D; Schellenberg, Gerard D et al. (2017) Genetic influences on cognition in progressive supranuclear palsy. Mov Disord 32:1764-1771
Litvan, Irene; Lees, Peter S J; Cunningham, Christopher R et al. (2016) Environmental and occupational risk factors for progressive supranuclear palsy: Case-control study. Mov Disord 31:644-52
Figge, David A; Standaert, David G (2016) SNPing SCNA regulatory elements gives a CRISPR view of genetic susceptibility in Parkinson's disease. Mov Disord 31:1479
Calabresi, Paolo; Standaert, David G; Chiasserini, Davide et al. (2016) Biomarkers in Parkinson's disease: From pathophysiology to early diagnosis. Mov Disord 31:769-70
Fraser, Kyle B; Rawlins, Ashlee B; Clark, Rachel G et al. (2016) Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease. Mov Disord 31:1543-1550
Robert, Stephanie M; Buckingham, Susan C; Campbell, Susan L et al. (2015) SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma. Sci Transl Med 7:289ra86
Olanow, C Warren; Kieburtz, Karl; Odin, Per et al. (2014) Continuous intrajejunal infusion of levodopa-carbidopa intestinal gel for patients with advanced Parkinson's disease: a randomised, controlled, double-blind, double-dummy study. Lancet Neurol 13:141-9
Amara, Amy W; Standaert, David G (2013) Metabolomics and the search for biomarkers in Parkinson's disease. Mov Disord 28:1620-1