There is a marked gap between our ability to treat neurologic diseases and our rapidly increasing understanding of normal nervous system function, disease pathogenesis, and disease pathophysiology. Improving treatment of neurologic diseases requires considerably improved integration of burgeoning basic neuroscience with clinical practice across the translational spectrum from basic discovery through translational and clinical research. An obstacle to improved integration of disease-oriented neuroscience research activities and more efficient translation is a deficit of appropriately trained clinician-neuroscientists. American medical schools graduate significant numbers of physicians with substantial research experience, including MD/PhDs and individuals with significant experience with and formal training in clinical research. The traditional clinical training structure, however, impedes the ability of these talented and well trained individuals to efficiently initiate productive, independent research careers. We propose continuation of a residency-fellowship based training program integrating residency-fellowship based clinical training with mentored research training to move talented and experienced trainees in Neurology, Neurosurgery, and Neuropathology to the initial stage of an independent career. The University of Michigan Clinical Neuroscientist Training Program (UMCNTP) prepares talented clinician-neuroscientists for independent research careers across the full spectrum of disease-oriented neuroscience research. The UMCNTP is an integrated residency-fellowship program preparing talented fledgling clinician-neuroscientists for successful applications for initial independent career support. The UMCNTP melds productive mentored research experience under the guidance of experienced senior investigators with focused didactic and hands-on career training to prepare UMCNTP trainees for successful career development applications such as K08, K23, VA CDA, or equivalents. Our residency programs matriculate talented individuals without significant prior research experience. For those individuals, the UMCNTP offers an integrated residency-fellowship-PhD training program in Neuroscience and related disciplines. The UMCNTP features a strong roster of mentors in the Depts. of Neurology, Neurosurgery, and Pathology, a training program based on highly successful prior experiences with training clinician- neuroscientists, utilizes excellent career development resources available at the University of Michigan, and draws on the great diversity and general excellence of the Neuroscience research community of the University of Michigan.

Public Health Relevance

Physician-neuroscientists bring indispensable skills to disease-oriented research and facilitate the integration of research and clinical practice. This program will improve the supply of physician-neuroscientists starting independent research careers.

National Institute of Health (NIH)
National Institute of Neurological Disorders and Stroke (NINDS)
Education Projects (R25)
Project #
Application #
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Schools of Medicine
Ann Arbor
United States
Zip Code
McGinley, Lisa M; Kashlan, Osama N; Chen, Kevin S et al. (2017) Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice. Ann Clin Transl Neurol 4:749-755
Chen, Kevin S; McIntyre, Jeremy C; Lieberman, Andrew P et al. (2016) Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation. Acta Neuropathol 131:639-40
McGinley, Lisa M; Sims, Erika; Lunn, J Simon et al. (2016) Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease. Stem Cells Transl Med 5:379-91
Chen, Kevin S; Sakowski, Stacey A; Feldman, Eva L (2016) Intraspinal stem cell transplantation for amyotrophic lateral sclerosis. Ann Neurol 79:342-53
Goutman, Stephen A; Chen, Kevin S; Feldman, Eva L (2015) Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:428-48
Callaghan, Brian C; Price, Raymond S; Chen, Kevin S et al. (2015) The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review. JAMA Neurol 72:1510-8