The Memorial Sloan-Kettering Cancer Center, The Rockefeller University, and the Weill Cornell Medical College are seeking federal funding to support three trainees in their Tri-Institutional Training Program in Laboratory Animal Medicine and Science (TTP-LAMS). The training program structure and the research environment and facilities utilized for training are unique and unparalleled. Trainees are mentored by highly experienced TTP-LAMS program faculty including board-certified laboratory animal veterinarians (6) and comparative pathologists (3), as well as specialists in biomedical imaging, vivarium operations and administration, regulatory affairs, monoclonal antibody production, and gene-targeting. Trainees are exposed to world-class faculty conducting biomedical research in diverse scientific disciplines. The tri-institutional faculty is among the most distinguished medicl and biomedical scientists in the world. The three institutions are the home for more than 37 members of the National Academy of Sciences and 8 Nobel laureates receiving more than 900 NIH awards totalling ~$ 300 M annually. Training is conducted within 14 state-of-the-art tri- institutional vivaria in which an average daily census of greater than 300,000 animals representing 14 species is maintained. The multi-disciplinary Laboratory of Comparative Pathology, providing anatomic and clinical pathology services, and various research core facilities are at the disposal of the trainee. The 3-year TTP- LAMS program is divided into two principal components: experiential and didactic. The experiential component is divided into two principal areas: Clinical, Management, and Administrative Training (CMAT) and independent Research Training. CMAT introduces trainees to all aspects of academic animal resource program management and operations as well as the clinical care and research utilization of laboratory animal species. There are nine CMAT rotations of varying lengths completed during 93 weeks. Research training (63 weeks) provides trainees the opportunity to apply the scientific method to a basic or clinical research project and to develop an appreciation for the process of scientific discovery. Didactic training includes the completion of graduate level courses offered by the Weill Cornell Graduate School of Medical Sciences, attending various program sessions including weekly a clinical and pathology conference and a laboratory animal medicine and science seminar series (providing ~ 230 h total contact time), as well as biweekly biosecurity case conferences and journal club.

Public Health Relevance

Laboratory animals are vital to basic and translational biomedical research activities in the United States. The discoveries made utilizing laboratory animals in numerous scientific disciplines have resulted in countless and far-reaching improvements to human as well as animal health and welfare. Laboratory animal veterinarians serve as stewards for this critical resource providing the necessary expertise to ensure the animals'health and well-being. Training in laboratory animal medicine is cursory, at best, in America's colleges and schools of veterinary medicine. Veterinarians seeking expertise in this discipline generally complete post- graduate specialty training at an academic, government or pharmaceutical biomedical research center in which laboratory animals are used in support of the research enterprise. This award will allow the tri-institutional consortium, consisting of the Memorial Sloan-Kettering Cancer Center, The Rockefeller University, and the Weill Cornell Medical College to provide post- graduate specialty training in laboratory animal medicine to three veterinarians.

National Institute of Health (NIH)
Office of The Director, National Institutes of Health (OD)
Education Projects (R25)
Project #
Application #
Study Section
Special Emphasis Panel (ZRR1-CM-4 (01))
Program Officer
Moro, Manuel H
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Sloan-Kettering Institute for Cancer Research
New York
United States
Zip Code
Gerwin, Philip M; Norinsky, Rada M; Tolwani, Ravi J (2018) Using a Time-Driven Activity-Based Costing Model To Determine the Actual Cost of Services Provided by a Transgenic Core. J Am Assoc Lab Anim Sci 57:157-160
Gerwin, Philip M; Ricart Arbona, Rodolfo J; Riedel, Elyn R et al. (2017) Evaluation of Traditional and Contemporary Methods for Detecting Syphacia obvelata and Aspiculuris tetraptera in Laboratory Mice. J Am Assoc Lab Anim Sci 56:32-41
Russell, James; Pillarsetty, Nagavarakishore; Kramer, Robin M et al. (2017) In Vitro and In Vivo Comparison of Gemcitabine and the Gemcitabine Analog 1-(2'-deoxy-2'-fluoroarabinofuranosyl) Cytosine (FAC) in Human Orthotopic and Genetically Modified Mouse Pancreatic Cancer Models. Mol Imaging Biol 19:885-892
Gerwin, Philip M; Ricart Arbona, Rodolfo J; Riedel, Elyn R et al. (2017) PCR Testing of IVC Filter Tops as a Method for Detecting Murine Pinworms and Fur Mites. J Am Assoc Lab Anim Sci 56:752-761
Kramer, Robin M; Russell, James; Humm, John L (2015) Distribution of Gemcitabine Is Nearly Homogenous in Two Orthotopic Murine Models of Pancreatic Cancer. Cancer Biother Radiopharm 30:299-304
Thorek, Daniel L J; Kramer, Robin M; Chen, Qing et al. (2015) Reverse-Contrast Imaging and Targeted Radiation Therapy of Advanced Pancreatic Cancer Models. Int J Radiat Oncol Biol Phys 93:444-53