Simian immunodeficiency virus (SIV) infection of macaque monkeys is an important model for the study of AIDS. The nucleotide sequence similarities to HIV and ability to induce AIDS in macaques make SIVs and their infection of these monkeys particularly important models for the development of AIDS vaccine strategies. In investigating the immune response to SIV in macaques, it will be important therefore to define the genes and gene products of the macaque's MHC. The investigator will therefore first characterize the MHC genes and gene products of the rhesus monkey and, and second explore the possible relationships between certain MHC haplotypes and length of survival after SIV infection in this species.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AI032426-01
Application #
3456064
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1992-03-01
Project End
1992-07-31
Budget Start
1992-03-01
Budget End
1992-07-31
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Harvard University
Department
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
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Slukvin, I I; Boyson, J E; Watkins, D I et al. (1998) The rhesus monkey analogue of human lymphocyte antigen-G is expressed primarily in villous syncytiotrophoblasts. Biol Reprod 58:728-38
Knapp, L A; Cadavid, L F; Eberle, M E et al. (1997) Identification of new mamu-DRB alleles using DGGE and direct sequencing. Immunogenetics 45:171-9
Knapp, L A; Lehmann, E; Piekarczyk, M S et al. (1997) A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens 50:657-61

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