Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AR044219-01
Application #
2083921
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1996-07-20
Project End
2001-06-30
Budget Start
1996-07-20
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Vermont & St Agric College
Department
Physiology
Type
Schools of Medicine
DUNS #
066811191
City
Burlington
State
VT
Country
United States
Zip Code
05405
Yengo, Christopher M; De La Cruz, Enrique M; Chrin, Lynn R et al. (2002) Actin-induced closure of the actin-binding cleft of smooth muscle myosin. J Biol Chem 277:24114-9
Yengo, Christopher M; Berger, Christopher L (2002) Fluorescence resonance energy transfer in acto-myosin complexes. Results Probl Cell Differ 36:21-30
Yengo, C M; Chrin, L R; Rovner, A S et al. (2000) Tryptophan 512 is sensitive to conformational changes in the rigid relay loop of smooth muscle myosin during the MgATPase cycle. J Biol Chem 275:25481-7
Cooper, W C; Chrin, L R; Berger, C L (2000) Detection of fluorescently labeled actin-bound cross-bridges in actively contracting myofibrils. Biophys J 78:1449-57
MacLean, J J; Chrin, L R; Berger, C L (2000) Dynamics at Lys-553 of the acto-myosin interface in the weakly and strongly bound states. Biophys J 78:1441-8
Yengo, C M; Chrin, L; Rovner, A S et al. (1999) Intrinsic tryptophan fluorescence identifies specific conformational changes at the actomyosin interface upon actin binding and ADP release. Biochemistry 38:14515-23
Yengo, C M; Fagnant, P M; Chrin, L et al. (1998) Smooth muscle myosin mutants containing a single tryptophan reveal molecular interactions at the actin-binding interface. Proc Natl Acad Sci U S A 95:12944-9
Warshaw, D M; Hayes, E; Gaffney, D et al. (1998) Myosin conformational states determined by single fluorophore polarization. Proc Natl Acad Sci U S A 95:8034-9