This new application seeks to test the involvement of the p53 protein in the evolution of prostate cancer to an androgen-independent state.
Aim 1 is to determine the growth response to androgens of androgen-sensitive human prostate cell lines in vivo and in vitro.
Aim 2 is to study the impact of inactivation of the p53 protein on growth responses to androgens in androgen-sensitive human prostate cancer cell lines.
Aim 3 is to determine the effects of expressing a wild type p53 gene in androgen-insensitive prostate cancer cell lines lacking endogenous p53 protein.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA075499-02
Application #
2733391
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Mohla, Suresh
Project Start
1997-07-01
Project End
2002-06-30
Budget Start
1998-07-01
Budget End
1999-06-30
Support Year
2
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Dentistry
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
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