Abstract

The proposed project is a cross-sectional and longitudinal clinical study of oral manifestations of HIV and periodontal disease status among a rural population of 675 HIV- infected persons in North Carolina, of whom approximately 54% will be blacks and 25% will be women; two year longitudinal follow-up is expected to be available in 381 persons. The principal investigator, Dr. Patton will administer a standardized interview questionnaire, conduct an oral clinical examination, and supervise collection of data from medical records on medical history, HIV disease classification, CD4 count, and medication; the patients will be referred from the HIV clinic at the same institution. The study will assess the impact of illicit drugs, alcohol, tobacco, gender, and race, as well as CD4 counts and disease status on the oral manifestations of HIV disease.The hypotheses are that HIV- infected blacks in rural North Carolina will have a greater extent and severity of periodontal disease, that differential access to oral health care may play an important role in oral disease progression, and that oral clinical signs of HIV infection play a critical role in initial serologic HIV diagnosis in blacks and females in the Southeast.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DE011369-04
Application #
2545665
Study Section
Special Emphasis Panel (ZDE1-YS (33))
Project Start
1994-09-30
Project End
1999-09-29
Budget Start
1997-09-30
Budget End
1998-09-29
Support Year
4
Fiscal Year
1997
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Dentistry
Type
Schools of Dentistry
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Chattopadhyay, Amit; Patton, Lauren L (2013) Smoking as a risk factor for oral candidiasis in HIV-infected adults. J Oral Pathol Med 42:302-8
Chattopadhyay, Amit; Patton, Lauren L (2007) Risk indicators for HIV-associated jointly occurring oral candidiasis and oral hairy leukoplakia. AIDS Patient Care STDS 21:825-32
Chattopadhyay, Amit; Caplan, Daniel J; Slade, Gary D et al. (2005) Risk indicators for oral candidiasis and oral hairy leukoplakia in HIV-infected adults. Community Dent Oral Epidemiol 33:35-44
Chattopadhyay, Amit; Caplan, Daniel J; Slade, Gary D et al. (2005) Incidence of oral candidiasis and oral hairy leukoplakia in HIV-infected adults in North Carolina. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99:39-47
Chattopadhyay, Amit; Gray, Laurie R; Patton, Lauren L et al. (2004) Salivary secretory leukocyte protease inhibitor and oral candidiasis in human immunodeficiency virus type 1-infected persons. Infect Immun 72:1956-63
Patton, Lauren L; Strauss, Ronald P; McKaig, Rosemary G et al. (2003) Perceived oral health status, unmet needs, and barriers to dental care among HIV/AIDS patients in a North Carolina cohort: impacts of race. J Public Health Dent 63:86-91
Patton, L L (2001) Ability of HIV/AIDS patients to self-diagnose oral opportunistic infections. Community Dent Oral Epidemiol 29:23-9
Freel, S A; Williams, J M; Nelson, J A et al. (2001) Characterization of human immunodeficiency virus type 1 in saliva and blood plasma by V3-specific heteroduplex tracking assay and genotype analyses. J Virol 75:4936-40
Shugars, D C; Patton, L L; Freel, S A et al. (2001) Hyper-excretion of human immunodeficiency virus type 1 RNA in saliva. J Dent Res 80:414-20
Patton, L L; McKaig, R; Strauss, R et al. (2000) Changing prevalence of oral manifestations of human immuno-deficiency virus in the era of protease inhibitor therapy. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 89:299-304

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