Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK049691-02
Application #
2150564
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1995-09-25
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Li, Chao; Iness, Audra; Yoon, Jennifer et al. (2015) Noncanonical STAT3 activation regulates excess TGF-?1 and collagen I expression in muscle of stricturing Crohn's disease. J Immunol 194:3422-31
Li, Chao; Vu, Kent; Hazelgrove, Krystina et al. (2015) Increased IGF-IEc expression and mechano-growth factor production in intestinal muscle of fibrostenotic Crohn's disease and smooth muscle hypertrophy. Am J Physiol Gastrointest Liver Physiol 309:G888-99
Li, Chao; Kuemmerle, John F (2014) Mechanisms that mediate the development of fibrosis in patients with Crohn's disease. Inflamm Bowel Dis 20:1250-8
Li, Chao; Flynn, Robert S; Grider, John R et al. (2013) Increased activation of latent TGF-?1 by ?V?3 in human Crohn's disease and fibrosis in TNBS colitis can be prevented by cilengitide. Inflamm Bowel Dis 19:2829-39
Kuemmerle, John F (2012) Insulin-like growth factors in the gastrointestinal tract and liver. Endocrinol Metab Clin North Am 41:409-23, vii
Mahavadi, Sunila; Flynn, Robert S; Grider, John R et al. (2011) Amelioration of excess collagen I?I, fibrosis, and smooth muscle growth in TNBS-induced colitis in IGF-I(+/-) mice. Inflamm Bowel Dis 17:711-9
Flynn, Robert S; Mahavadi, Sunila; Murthy, Karnam S et al. (2011) Endogenous IGFBP-3 regulates excess collagen expression in intestinal smooth muscle cells of Crohn's disease strictures. Inflamm Bowel Dis 17:193-201
Grider, J R; Heuckeroth, R O; Kuemmerle, J F et al. (2010) Augmentation of the ascending component of the peristaltic reflex and substance P release by glial cell line-derived neurotrophic factor. Neurogastroenterol Motil 22:779-86
Flynn, Robert S; Murthy, Karnam S; Grider, John R et al. (2010) Endogenous IGF-I and alphaVbeta3 integrin ligands regulate increased smooth muscle hyperplasia in stricturing Crohn's disease. Gastroenterology 138:285-93
Grider, John R; Mahavadi, Sunila; Li, Yan et al. (2009) Modulation of motor and sensory pathways of the peristaltic reflex by cannabinoids. Am J Physiol Gastrointest Liver Physiol 297:G539-49

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