Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29GM051372-03
Application #
2189855
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Kindler, Christoph H; Paul, Matthias; Zou, Hilary et al. (2003) Amide local anesthetics potently inhibit the human tandem pore domain background K+ channel TASK-2 (KCNK5). J Pharmacol Exp Ther 306:84-92
Gray, A T; Zhao, B B; Kindler, C H et al. (2000) Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5. Anesthesiology 92:1722-30
Kindler, C H; Verotta, D; Gray, A T et al. (2000) Additive inhibition of nicotinic acetylcholine receptors by corticosteroids and the neuromuscular blocking drug vecuronium. Anesthesiology 92:821-32
Kindler, C H; Pietruck, C; Yost, C S et al. (2000) Localization of the tandem pore domain K+ channel TASK-1 in the rat central nervous system. Brain Res Mol Brain Res 80:99-108
Chavez, R A; Gray, A T; Zhao, B B et al. (1999) TWIK-2, a new weak inward rectifying member of the tandem pore domain potassium channel family. J Biol Chem 274:7887-92
Gray, A T; Kindler, C H; Sampson, E R et al. (1999) Assignment of KCNK6 encoding the human weak inward rectifier potassium channel TWIK-2 to chromosome band 19q13.1 by radiation hybrid mapping. Cytogenet Cell Genet 84:190-1
Yost, C S (1999) Potassium channels: basic aspects, functional roles, and medical significance. Anesthesiology 90:1186-203
Kindler, C H; Yost, C S; Gray, A T (1999) Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem. Anesthesiology 90:1092-102
Yost, C S; Hampson, A J; Leonoudakis, D et al. (1998) Oleamide potentiates benzodiazepine-sensitive gamma-aminobutyric acid receptor activity but does not alter minimum alveolar anesthetic concentration. Anesth Analg 86:1294-300
Leonoudakis, D; Gray, A T; Winegar, B D et al. (1998) An open rectifier potassium channel with two pore domains in tandem cloned from rat cerebellum. J Neurosci 18:868-77

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