Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29HL040796-05
Application #
3472141
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-07-01
Project End
1992-08-31
Budget Start
1992-07-01
Budget End
1992-08-31
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Oklahoma Medical Research Foundation
Department
Type
DUNS #
937727907
City
Oklahoma City
State
OK
Country
United States
Zip Code
73104
Bevers, E M; Wiedmer, T; Comfurius, P et al. (1995) The complex of phosphatidylinositol 4,5-bisphosphate and calcium ions is not responsible for Ca2+-induced loss of phospholipid asymmetry in the human erythrocyte: a study in Scott syndrome, a disorder of calcium-induced phospholipid scrambling. Blood 86:1983-91
Kojima, H; Newton-Nash, D; Weiss, H J et al. (1994) Production and characterization of transformed B-lymphocytes expressing the membrane defect of Scott syndrome. J Clin Invest 94:2237-44
Chang, C P; Zhao, J; Wiedmer, T et al. (1993) Contribution of platelet microparticle formation and granule secretion to the transmembrane migration of phosphatidylserine. J Biol Chem 268:7171-8
Wiedmer, T; Hall, S E; Ortel, T L et al. (1993) Complement-induced vesiculation and exposure of membrane prothrombinase sites in platelets of paroxysmal nocturnal hemoglobinuria. Blood 82:1192-6
Bevers, E M; Wiedmer, T; Comfurius, P et al. (1992) Defective Ca(2+)-induced microvesiculation and deficient expression of procoagulant activity in erythrocytes from a patient with a bleeding disorder: a study of the red blood cells of Scott syndrome. Blood 79:380-8
Dahlback, B; Wiedmer, T; Sims, P J (1992) Binding of anticoagulant vitamin K-dependent protein S to platelet-derived microparticles. Biochemistry 31:12769-77
Gerrard, J M; Lint, D; Sims, P J et al. (1991) Identification of a platelet dense granule membrane protein that is deficient in a patient with the Hermansky-Pudlak syndrome. Blood 77:101-12
Gilbert, G E; Sims, P J; Wiedmer, T et al. (1991) Platelet-derived microparticles express high affinity receptors for factor VIII. J Biol Chem 266:17261-8
Sims, P J; Wiedmer, T (1991) The response of human platelets to activated components of the complement system. Immunol Today 12:338-42
Wiedmer, T; Sims, P J (1991) Participation of protein kinases in complement C5b-9-induced shedding of platelet plasma membrane vesicles. Blood 78:2880-6

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