Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
5R33AI080557-05
Application #
8311572
Study Section
Special Emphasis Panel (NSS)
Program Officer
Dicarlo-Cohen, Andrea L
Project Start
2008-07-08
Project End
2013-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
5
Fiscal Year
2012
Total Cost
$406,085
Indirect Cost
$65,706
Name
Bloodcenter of Wisconsin, Inc.
Department
Type
DUNS #
057163172
City
Milwaukee
State
WI
Country
United States
Zip Code
53233
Kerschen, E; Hernandez, I; Zogg, M et al. (2015) Survival advantage of heterozygous factor V Leiden carriers in murine sepsis. J Thromb Haemost 13:1073-80
Liang, Hai Po H; Kerschen, Edward J; Hernandez, Irene et al. (2015) EPCR-dependent PAR2 activation by the blood coagulation initiation complex regulates LPS-triggered interferon responses in mice. Blood 125:2845-54
Liang, Hai Po H; Kerschen, Edward J; Basu, Sreemanti et al. (2015) Coagulation factor V mediates inhibition of tissue factor signaling by activated protein C in mice. Blood 126:2415-23
Weiler, Hartmut (2014) Inflammation-associated activation of coagulation and immune regulation by the protein C pathway. Thromb Res 133 Suppl 1:S32-4
Geiger, Hartmut; Pawar, Snehalata A; Kerschen, Edward J et al. (2012) Pharmacological targeting of the thrombomodulin-activated protein C pathway mitigates radiation toxicity. Nat Med 18:1123-9
Kerschen, Edward; Hernandez, Irene; Zogg, Mark et al. (2010) Activated protein C targets CD8+ dendritic cells to reduce the mortality of endotoxemia in mice. J Clin Invest 120:3167-78