This R21/R33 application is in response to RFA-DA-09-020. It seeks support to address one research area recommended by this RFA ?Secondary data analyses of multiple trials in the NIDA Clinical Trials Network (CTN).? By capitalizing on the CTN?s wealth of multisite treatment data from multiple trials, we seek to, in the R21 phase (Year 1), 1) identify and create analyzable flat data files from the raw trial data (stacked format), 2) generate study variables and codebooks by programming scoring algorithms for multiple standardized clinical instruments, 3) evaluate the extent of missing data, and 4) examine baseline clinical profiles (substance use and diagnoses, mental health, and quality of life) of trial participants by gender and race/ethnicity in order to guide the R33 phase of work. In the R33 phase (Years 2-4), we plan to evaluate the construct, concurrent, and predictive validity of categorical and dimensional models of substance use diagnoses. The multisite CTN trials present an unparalleled, excellent opportunity to explore and evaluate these clinically and scientifically important issues directly related to treatment outcomes and to the emerging Diagnostic and Statistical Manual Version-IV (DSM-V).
Study Aims for R33 are to 1) investigate measurement equivalence of DSM-IV diagnostic questions by gender and race/ethnicity, 2) evaluate the construct and concurrent validity of DSM-IV substance use diagnoses using categorical, dimensional, and integrated hybrid models of diagnostic classification, 3) determine empirically defined drug dependence subtypes (an integrated hybrid model) in predicting subsequent outcomes and to explore the mediator and moderators of the associations, and 4) evaluate empirically-defined comorbid drug dependence subtypes in predicting subsequent outcomes and to explore the mediator and moderators of the associations. Gender/sex differences will be examined in all analyses either through stratified analyses or the inclusions of interaction terms as appropriate.

Public Health Relevance

Randomized clinical trials dominate treatment research today. Findings from the proposed study will make unique contributions to randomized addiction treatment research. They will help inform gender and racial/ethnic differences in the clinical profiles of substance use diagnoses, the quality and clinical utility of self-report diagnostic measures, interpretations of study results within the CTN, and future designs and analyses of addiction treatment trials.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Exploratory/Developmental Grants Phase II (R33)
Project #
Application #
Study Section
Special Emphasis Panel (ZDA1-NXR-B (02))
Program Officer
Ducharme, Lori
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Duke University
Schools of Medicine
United States
Zip Code
Wu, L-T; Blazer, D G (2015) Substance use disorders and co-morbidities among Asian Americans and Native Hawaiians/Pacific Islanders. Psychol Med 45:481-94
Carroll Chapman, Shawna L; Wu, Li-Tzy (2014) E-cigarette prevalence and correlates of use among adolescents versus adults: a review and comparison. J Psychiatr Res 54:43-54
Wu, Li-Tzy; Brady, Kathleen T; Mannelli, Paolo et al. (2014) Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a national study. J Psychiatr Res 50:26-35
Wu, Li-Tzy; Swartz, Marvin S; Brady, Kathleen T et al. (2014) Nonmedical stimulant use among young Asian-Americans, Native Hawaiians/Pacific Islanders, and mixed-race individuals aged 12-34 years in the United States. J Psychiatr Res 59:189-99
Zhang, Xiaoyun; Wu, Li-Tzy (2014) Suicidal ideation and substance use among adolescents and young adults: a bidirectional relation? Drug Alcohol Depend 142:63-73
Chapman, Shawna L Carroll; Wu, Li-Tzy (2014) Suicide and substance use among female veterans: a need for research. Drug Alcohol Depend 136:1-10
Mannelli, Paolo; Wu, Li-Tzy; Peindl, Kathleen S et al. (2014) Extended release naltrexone injection is performed in the majority of opioid dependent patients receiving outpatient induction: a very low dose naltrexone and buprenorphine open label trial. Drug Alcohol Depend 138:83-8
Wu, Li-Tzy; Blazer, Dan G (2014) Substance use disorders and psychiatric comorbidity in mid and later life: a review. Int J Epidemiol 43:304-17
Pilowsky, Daniel J; Wu, Li-Tzy (2013) Screening instruments for substance use and brief interventions targeting adolescents in primary care: a literature review. Addict Behav 38:2146-53
Chapman, Shawna L Carroll; Wu, Li-Tzy (2013) Substance Use among Adolescent Mothers: A Review. Child Youth Serv Rev 35:806-815

Showing the most recent 10 out of 33 publications