The novel concept of GAP (Group-Assistant-Purification) chemistry has been established recently by the PI's group;the GAP chemistry shows organic synthesis of amino compounds can be achieved without the use of chromatography and crystallization. This ECHEM proposal is planned to explore the GAP chemistry for asymmetric synthesis of a series of unnatural amino acids and - and -amino phosphonates to serve for neuro drug design and synthesis. The GAP chemistry will also benefit the synthesis of neuro and general peptides and peptidomimetics as to avoid the disadvantages of traditional solid-phase-peptide synthesis (SPPS) and solution-phase-peptide synthesis. Although the liquid-phase-peptide synthesis (LPPS) was developed as a hybrid technique, this method was only suitable for simple amide bond formations for peptide synthesis;it suffers from the extremely large molecular weight of template which makes it inconvenient to produce large amounts of products;a long period is often needed to generate crystalline precursors and products (sometimes, it even takes one week) by carefully controlling solidification/crystalization conditions. In contrast, the GAP chemistry tool for this project will have advantages of solid-phase-peptide synthesis (SPPS), solution-phase-peptide synthesis (SoPPS) and liquid-phase-peptide synthesis (LPPS) including quick purification by filtration, a potential automated manual option (for SPPS);easy scale-up from mg to kg, and there is no need for excess amounts of reagents or expensive instrument (for SoPPS and LPPS). So far, an efficient method which enables asymmetric synthesis subsequently followed by peptide synthesis not been documented yet. In this ECHEM project, the resulting special chiral amino acids attached by N- phosphonyl and N-phosphinyl moieties from the GAP synthesis can be utilized for the design and synthesis of important drug abuse related targets, such as neuropeptides,N-arachidonoyl-Gly derivatives, N-arachidonoyl enthanolamines,hemopressin and neurotensin analogs. Promising preliminary results obtained by the PI's group make this proposal feasible. In the past 14 years, the PI has trained nearly 60 undergraduate students and 18 graduates (including 5 collaborative graduates in China, one of them is a Chinese Olympic gold medalist on chemistry) on conducting organic and bioorganic/medicinal research. All of these graduates and nearly 30 undergraduates achieved research publications as co-authors with the PI and successfully found professional positions.

Public Health Relevance

LI, GUIGEN This proposal is planned to explore novel strategies for the asymmetric synthesis of unnatural amino acids, - and -amino phosphonic acids for neuro drug design and synthesis. A new concept of GAP chemistry is also applied to the synthesis of neuro peptides and peptidomimetics to make these syntheses environmentally friendly without tedious work-up. The GAP peptide synthesis can avoid disadvantages of known methods. The preliminary results have been obtained in the PI's lab, which makes this proposal feasible. Thus far, the PI's group has trained nearly 60 undergraduate students and 18 graduates in conducting research in organic/medicinal research including a Chinese Olympic Gold Medalist on Chemistry. All graduates and nearly 30 undergraduates achieved research publications with the PI. All of these students either successfully entered medical schools or found jobs in pharmaceutical companies. PHS 398/2590 (Rev. 09/04) Page __

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Exploratory/Developmental Grants Phase II (R33)
Project #
4R33DA031860-03
Application #
8655620
Study Section
Special Emphasis Panel (NSS)
Program Officer
Hillery, Paul
Project Start
2011-06-15
Project End
2015-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
3
Fiscal Year
2013
Total Cost
$353,074
Indirect Cost
$103,278
Name
Texas Tech University
Department
Type
DUNS #
041367053
City
Lubbock
State
TX
Country
United States
Zip Code
79409
Hao, Wen-Juan; Du, Yan; Wang, Dan et al. (2016) Catalytic Diazosulfonylation of Enynals toward Diazoindenes via Oxidative Radical-Triggered 5-exo-trig Carbocyclizations. Org Lett 18:1884-7
Yang, Bing; Shen, Minxing; Ji, Xiaozhou et al. (2016) Chiral N-Phosphonyl Imines for an Aza-Morita-Baylis-Hillman Reaction via Group-Assisted Purification (GAP) Chemistry. J Org Chem 81:2488-93
Wang, Ai-Fang; Zhu, Yi-Long; Wang, Shu-Liang et al. (2016) Metal-Free Radical Haloazidation of Benzene-Tethered 1,7-Enynes Leading to Polyfunctionalized 3,4-Dihydroquinolin-2(1H)-ones. J Org Chem 81:1099-105
Zhu, Yi-Long; Jiang, Bo; Hao, Wen-Juan et al. (2016) A new cascade halosulfonylation of 1,7-enynes toward 3,4-dihydroquinolin-2(1H)-ones via sulfonyl radical-triggered addition/6-exo-dig cyclization. Chem Commun (Camb) 52:1907-10
Fan, Wei; Li, Yan-Rong; Jiang, Bo et al. (2016) Cascade bicyclization of triethylammonium thiolates with hydrazines: efficient access to pyrazolo[3,4-c]quinolines. Org Biomol Chem 14:9080-9087
Wang, Nan-Nan; Huang, Lei-Rong; Hao, Wen-Juan et al. (2016) Synergistic Rhodium/Copper Catalysis: Synthesis of 1,3-Enynes and N-Aryl Enaminones. Org Lett 18:1298-301
Wang, Nan-Nan; Hao, Wen-Juan; Zhang, Tian-Shu et al. (2016) Metal-free C(sp(3))-H functionalization: oxidative carbo-oxygenation of α-diazo carbonyls via radical dediazotization. Chem Commun (Camb) 52:5144-7
Fan, Wei; Li, Qun; Li, Yanrong et al. (2016) I2/O2-Enabled N-S Bond Formation to Access Functionalized 1,2,3-Thiadiazoles. Org Lett 18:1258-61
Gao, Qian; Hao, Wen-Juan; Liu, Feng et al. (2016) Unexpected isocyanide-based three-component bicyclization for the stereoselective synthesis of densely functionalized pyrano[3,4-c]pyrroles. Chem Commun (Camb) 52:900-3
Qiu, Jiang-Kai; Jiang, Bo; Zhu, Yi-Long et al. (2015) Catalytic Dual 1,1-H-Abstraction/Insertion for Domino Spirocyclizations. J Am Chem Soc 137:8928-31

Showing the most recent 10 out of 30 publications