Abstract

This application proposes studies in a variety of areas relating to the chemistry and biology of human lymphocytes. The problems being studied involve the molecular basis of immune recognition as well as factors which govern and regulate proliferation of human lymphocytes. The techniques being employed include protein chemistry and crystallography, molecular genetics, immunology and virology. Specific areas of investigation are 1) protein chemistry and crystallography of immune recognition molecules, 2) relationship of structure to function in class I and class II MHC molecules, 3) cloning the human major histocompatibility complex, especially the location of tumor necrosis factor genes within it, 4) expression of human class II antigens, 5) regulation of transcription of human class II MHC genes, 6) studies of T cell receptors particularly the role of the TCR gamma delta receptor in immunosurveillance, 7) the Epstein-Barr Virus particularly the nature of the viral functions which induce cell proliferations, 8) the role of the 4F2 protein in cell proliferation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA047554-05
Application #
3479714
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1988-09-30
Project End
1995-09-29
Budget Start
1992-09-30
Budget End
1993-09-29
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138

  Publications

Nieuwenhuis, Edward E S; Gillessen, Silke; Scheper, Rik J et al. (2005) CD1d and CD1d-restricted iNKT-cells play a pivotal role in contact hypersensitivity. Exp Dermatol 14:250-8
Deng, Lih-Wen; Chiu, Isaac; Strominger, Jack L (2004) MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A 101:757-62
Wong, Siew Heng; Santambrogio, Laura; Strominger, Jack L (2004) Caspases and nitric oxide broadly regulate dendritic cell maturation and surface expression of class II MHC proteins. Proc Natl Acad Sci U S A 101:17783-8
Koopman, Louise A; Kopcow, Hernan D; Rybalov, Basya et al. (2003) Human decidual natural killer cells are a unique NK cell subset with immunomodulatory potential. J Exp Med 198:1201-12
Potolicchio, Ilaria; Santambrogio, Laura; Strominger, Jack L (2003) Molecular interaction and enzymatic activity of macrophage migration inhibitory factor with immunorelevant peptides. J Biol Chem 278:30889-95
Re, Fabio; Strominger, Jack L (2002) Monomeric recombinant MD-2 binds toll-like receptor 4 tightly and confers lipopolysaccharide responsiveness. J Biol Chem 277:23427-32
Re, Fabio; Belyanskaya, Svetlana L; Riese, Richiard J et al. (2002) Granulocyte-macrophage colony-stimulating factor induces an expression program in neonatal microglia that primes them for antigen presentation. J Immunol 169:2264-73
Malik, Pratap; Klimovitsky, Polina; Deng, Lih-Wen et al. (2002) Uniquely conformed peptide-containing beta 2-microglobulin-free heavy chains of HLA-B2705 on the cell surface. J Immunol 169:4379-87
Boyson, Jonathan E; Erskine, Robert; Whitman, Mary C et al. (2002) Disulfide bond-mediated dimerization of HLA-G on the cell surface. Proc Natl Acad Sci U S A 99:16180-5
Rotzschke, Olaf; Lau, Julie M; Hofstatter, Maria et al. (2002) A pH-sensitive histidine residue as control element for ligand release from HLA-DR molecules. Proc Natl Acad Sci U S A 99:16946-50

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