This project seeks to investigate the role of nerves and other stromal cells in the development of digestive cancers, including stomach, esophageal, colon and pancreas. The project builds on previous work that suggests that these elements can regulate stem cells,a nd that inhibiting stromal cells in the microenvironment, it may be possible to inhibit the development of tumors.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
1R35CA210088-01
Application #
9186833
Study Section
Special Emphasis Panel (ZCA1)
Program Officer
Daschner, Phillip J
Project Start
2016-12-07
Project End
2023-11-30
Budget Start
2016-12-07
Budget End
2017-11-30
Support Year
1
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Hayakawa, Yoku; Sakitani, Kosuke; Konishi, Mitsuru et al. (2016) Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling. Cancer Cell :